World Journal of Urology

, Volume 37, Issue 2, pp 289–297 | Cite as

Combination of solifenacin and tamsulosin may provide additional beneficial effects for ureteral stent-related symptoms—outcomes from a network meta-analysis

  • Zhongyu Jian
  • Yuntian Chen
  • Qinyu Liu
  • Banghua Liao
  • Tongxin Yang
  • Hong Li
  • Kunjie WangEmail author



To systematically evaluate the different efficacy among generally used drugs for stent-related symptoms (SRS) with the method of network meta-analysis.


A systematic search was performed in the US National Library of Medicine’s life science database (Medline), Embase, the Cochrane Central Register of Controlled Trials, and the Cochrane Database for Systematic Reviews before December 2017. Analysis was performed under multivariate random-effects network model and effects of drugs were ranked with surface under the cumulative ranking (SUCRA) probabilities.


19 trials with 2036 patients investigating 4 different intervention including tamsulosin (Tam), alfuzosin (Alfu), solifenacin (Soli) and combination of Tam and Solif were finally included in our analysis. Tam plus Soli had the highest SUCRA on all aspects of ureteral stent symptom questionnaire: urinary symptoms (86.2%), body pain (85.0%), general health (80.5%), work performance (72.0%) and sexual performance (84.4%). Except for pain relief, Soli showed higher SUCRA than Tam or Alfu in rest respects. Tam and Alfu showed similar SUCRA on urinary symptoms (53.0 vs 48.7%) and body pain relief (61.9 vs 62.9%).


Tam plus Soli might be the most effective intervention for SRSs. As for monotherapy, Soli showed advantages in most respects except for pain relief compared to Tam or Alfu. Tam and Alfu showed similar efficacy on urinary symptoms and body pain relief.


Ureteral stent-related symptoms Network meta-analysis Drug therapies 



This article is supported by grants from 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZY2016104), Project of the Health and Family Planning Committee of SichuanProvince, The popularization and promotion of ureteroscopic technique in the treatment of upper urinary tract stones in primary hospitals (16PI294) and Project of Science and Technology Department of Chengdu, Research and application of urogenital suspension mesh (2016-HM02-00020-SF).

Author’s contribution

JZ and CY: project development, data collection and management, manuscript writing and revising; LQ: data collection, data analysis; LB and YT: data collection, data analysis; LH: data collection, data analysis; WK: project design and development, data interpretation, manuscript editing and revising. All authors read and approved the final manuscript.


This article is supported by grants from 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZY2016104), Project of the Health and Family Planning Committee of SichuanProvince, The popularization and promotion of ureteroscopic technique in the treatment of upper urinary tract stones in primary hospitals (16PI294) and Project of Science and Technology Department of Chengdu, Research and application of urogenital suspension mesh (2016-HM02-00020-SF).

Compliance with ethical standards

Conflict of interest

The authors of this article as well as all the included studies declare that they have no conflict of interest.

Ethical standards

The study protocol is compliant with ethical standards.

Supplementary material

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China HospitalSichuan UniversityChengduPeople’s Republic of China

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