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Validating the role of ABO blood type in risk of perioperative venous thromboembolism after radical cystectomy

  • Sumeet Bhanvadia
  • Kayvan Kazerouni
  • Soroush T. Bazargani
  • Gus Miranda
  • Jie Cai
  • Siamak Daneshmand
  • Hooman Djaladat
Original Article

Abstract

Purpose

To validate the relationship between ABO blood type and risk of VTE post-RC in a large retrospective database.

Methods

Patients with urothelial bladder cancer (UBC) who underwent RC (intent-to-cure) for whom ABO blood type was available between 2003 and 2015 were identified from our IRB-approved database. VTE was defined as deep vein thrombosis (DVT) or pulmonary embolism (PE) within 90 days of surgery. VTE prophylaxis consisted of immediate postoperative Coumadin (2003–2009), unfractionated heparin (UFH) during hospitalization (2009–2015), and UFH during hospitalization plus 4 weeks of enoxaparin after discharge (2013–2015). Univariable and multivariable analyses of the association of ABO blood type with postoperative, symptomatic VTE and oncologic outcomes were performed.

Results

Of 1341 patients, 595 (44.4%) were ABO type O and 746 (55.6%) were non-O (A, B and AB). 90 patients were diagnosed with VTE within 90 days of surgery (6.7%) (43% DVT-only, 57% PE ± DVT). On multivariable analysis non-O blood type was associated with a nearly twofold increased risk of VTE (OR = 1.94, 95% CI 1.215–3.098, p = 0.004). No difference in recurrence-free survival or overall survival was seen between ABO groups.

Conclusion

Non-O blood type is an independent, non-modifiable risk factor for postoperative VTE after RC. More comprehensive counseling and thromboprophylaxis should be considered in this high-risk group.

Keywords

MeSH Cystectomy Venous thromboembolism Urothelial carcinoma Bladder Thromboprophylaxis 

Notes

Author contributions

SB: data management; data analysis; manuscript editing; other (critical review). KK: data collection or management; data analysis; manuscript writing/editing, STB: data collection or management; data analysis; manuscript writing/editing. GM: data collection or management; data analysis. JC: data collection or management; Data analysis. SD: protocol/project development; manuscript editing; other (critical review). HD: Protocol/project development; data management; data analysis; manuscript editing; other (critical review).

Funding

None.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Norris Comprehensive Cancer CenterUSC Institute of UrologyLos AngelesUSA
  2. 2.USC School of Medicine, Norris Comprehensive Cancer CenterUSC Institute of UrologyLos AngelesUSA
  3. 3.University of Southern CaliforniaLos AngelesUSA

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