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World Journal of Urology

, Volume 36, Issue 2, pp 277–283 | Cite as

In vivo assessment of a novel biodegradable ureteral stent

  • Alexandre A. Barros
  • Carlos Oliveira
  • Ana J. Ribeiro
  • Riccardo Autorino
  • Rui L. Reis
  • Ana Rita C. Duarte
  • Estevão Lima
Original Article

Abstract

Purpose

To perform an in vivo assessment of a newly developed biodegradable ureteral stent (BUS) produced with natural-based polymers.

Methods

The BUS is based on a patented technology combining the injection process with the use of supercritical fluid technology. Study was conducted at ICVS—University of Minho (Braga, Portugal) and a total of ten domestic pigs were used. In seven animals, the experimental BUS stent was inserted, whereas in the remaining a commercially available stent was used (6-Fr Biosoft® duo stents, Porges Coloplast, Denmark). Post-stenting intravenous pyelogram was used to evaluate the degree of hydronephrosis. The in vivo stent degradation was measured as function of the weight loss. Moreover, the tensile properties of the BUS were tested during in vivo degradation. After maximum 10 days, animals were killed and necropsy was performed. Tissues were compared between the stented groups as well as between the non-stented contralateral ureters and stented ureters in each group. Biocompatibility was assessed by histopathological grading.

Results

In all cases, the BUS was only visible during the first 24 h on X-ray, and in all cases the BUS was completely degraded in urine after 10 days, as confirmed on necropsy. During the degradation process, the mechanical properties of the BUS decreased, while the commercial ureteral stents remained constant. At all time-points after stent insertion, the level of hydronephrosis was minimal. Overall, animals stented with BUS had an average grade of hydronephrosis which was lower compared to the controls. The BUS showed better pathological conditions, and hence better biocompatibility when compared with commercial stents.

Conclusions

Notwithstanding the limitations of the present study, the in vivo testing of our novel natural origin polymer-based BUS suggests this device to feature homogeneous degradation, good urine drainage, and high biocompatibility. Next steps will be to increase its stability, and to improve the radiopacity without compromising its degradation. Ultimately, clinical studies will be required to determine the safety and feasibility of its use in humans.

Keywords

Biodegradable Polymers Ureteral stent Ureteroscopy 

Notes

Acknowledgements

The research leading to these results has received funding from the ICVS/3B’s Associated Laboratory with the project reference POCI-01-0145-FEDER-007038, from the project “Novel smart and biomimetic materials for innovative regenerative medicine approaches” RL1—ABMR—NORTE-01-0124-FEDER-000016) cofinanced by North Portugal Regional Operational Programme (ON.2—O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). Alexandre Barros acknowledges his FCT PhD grant SFRH/BD/97203/2013. The authors acknowledge Teresa Oliveira and Tírcia C. Santos for the technical assistance on histopathology analysis.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Alexandre A. Barros
    • 1
    • 2
  • Carlos Oliveira
    • 2
    • 3
  • Ana J. Ribeiro
    • 4
  • Riccardo Autorino
    • 5
  • Rui L. Reis
    • 1
    • 2
  • Ana Rita C. Duarte
    • 1
    • 2
  • Estevão Lima
    • 2
    • 3
  1. 1.3B´s Research Group-Biomaterials, Biodegradables and BiomimeticsUniversity of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineGuimarãesPortugal
  2. 2.ICVS/3B’s-T Government Associate LaboratoryBraga/GuimarãesPortugal
  3. 3.School of Health Sciences, Life and Health Sciences Research Institute (ICVS)University of MinhoBragaPortugal
  4. 4.University School of Vasco da GamaCoimbraPortugal
  5. 5.Division of UrologyVirginia Commonwealth UniversityRichmondUSA

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