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World Journal of Urology

, Volume 35, Issue 1, pp 11–20 | Cite as

Why we should not routinely apply irreversible electroporation as an alternative curative treatment modality for localized prostate cancer at this stage

  • J. J. WendlerEmail author
  • R. Ganzer
  • B. Hadaschik
  • A. Blana
  • T. Henkel
  • K. U. Köhrmann
  • S. Machtens
  • A. Roosen
  • G. Salomon
  • L. Sentker
  • U. Witzsch
  • H. P. Schlemmer
  • D. Baumunk
  • J. Köllermann
  • M. Schostak
  • U. B. Liehr
Invited Review

Abstract

Irreversible electroporation (IRE), a new tissue ablation procedure available since 2007, could meet the requirements for ideal focal therapy of prostate cancer with its postulated features, especially the absence of a thermal ablation effect. Thus far, there is not enough evidence of its effectiveness or adverse effects to justify its use as a definitive treatment option for localized prostate cancer. Moreover, neither optimal nor individual treatment parameters nor uniform endpoints have been defined thus far. No advantages over established treatment procedures have as yet been demonstrated. Nevertheless, IRE is now being increasingly applied for primary prostate cancer therapy outside clinical trials, not least through active advertising in the lay press. This review reflects the previous relevant literature on IRE of the prostate or prostate cancer and shows why we should not adopt IRE as a routine treatment modality at this stage.

Keywords

Focal therapy Ablation Irreversible electroporation Prostate Localized prostate cancer Definitive treatment 

Notes

Authors’ contributions

J. J. Wendler is the corresponding author, wrote the manuscript, collected and analyzed the data, and developed the project. R. Ganzer, B. Hadaschik, A. Blana, T. Henkel, K. U. Köhrmann, S. Machtens, A. Roosen, G. Salomon, L. Sentker, U. Witzsch, H. P. Schlemmer and J. Köllermann edited and critically revised the manuscript and voted for internal consensus. D. Baumunk wrote and edited the manuscript. M. Schostak is the chief of academy, wrote the manuscript and developed the project. U. B. Liehr is a senior author, wrote the manuscript and developed the project.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical standards

For this type of study (review) formal consent is not required.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • J. J. Wendler
    • 1
    Email author
  • R. Ganzer
    • 5
  • B. Hadaschik
    • 3
  • A. Blana
    • 4
  • T. Henkel
    • 6
  • K. U. Köhrmann
    • 7
  • S. Machtens
    • 8
  • A. Roosen
    • 9
  • G. Salomon
    • 10
  • L. Sentker
    • 11
  • U. Witzsch
    • 12
  • H. P. Schlemmer
    • 13
  • D. Baumunk
    • 1
  • J. Köllermann
    • 2
  • M. Schostak
    • 1
  • U. B. Liehr
    • 1
  1. 1.Department of Urology and Pediatric UrologyMagdeburg University Medical CenterMagdeburgGermany
  2. 2.Institute of PathologySana Medical Center OffenbachOffenbachGermany
  3. 3.Department of UrologyRuprecht-Karls UniversityHeidelbergGermany
  4. 4.Department of Urology and Pediatric UrologyMedical Center FürthNurembergGermany
  5. 5.Department of UrologyUniversity of LeipzigLeipzigGermany
  6. 6.Urological Practice of Dr. Henkel and Dr. KahmannBerlinGermany
  7. 7.Department of UrologySt. Theresa HospitalMannheimGermany
  8. 8.Department of UrologySt. Maria HospitalBergisch-GladbachGermany
  9. 9.Department of UrologyAugusta-Krankenanstalt gGmbH BochumBochumGermany
  10. 10.Martini ClinicHamburg-Eppendorf University Medical CenterHamburgGermany
  11. 11.Joint Urological PracticeSinsheimGermany
  12. 12.Department of Urology and Pediatric UrologyNorthwest Hospital & Medical CenterFrankfurt/MainGermany
  13. 13.Department of RadiologyGerman Cancer Research CenterHeidelbergGermany

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