Management of low- and intermediate-risk prostate cancer
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Van der Poel et al. [1] summarize the recent developments and their implications for the management of prostate cancer. Lellig et al. [2] and Billing et al. [3] examine the current status of MRI in active surveillance, particularly for predicting tumor stage and site. Here it becomes obvious that the diagnostic accuracy of dedicated centers is not reproduced by non-specialized radiologists. Renard-Penna et al. [4] describe promising developments of imaging and molecular pathology in the stratification of patients with early prostate cancer.
The second part of the manuscripts is dedicated to focal therapy of prostate cancer. Lebdai et al. [5] carefully describe a ‘standardized operating procedure’ (SOP) for vascular-targeted photodynamic therapy (VTP) followed by a pooled analysis of three phase 2 studies by Azzouzi et al. [6]. The histopathologic results of focal therapy and cryotherapy are summarized by Shah et al. [7], and oncological and functional outcomes of VTP are reviewed by Azzouzi et al. The feasibility of salvage surgery after VTP is described by Lebdai et al. [8]. Karl et al. [9] describe a carefully designed multicenter study on the PSA recurrence rate of men with pT2 prostate cancer and a positive surgical margin without any adjuvant therapy.
We believe that the advances in the management of low- and intermediate-risk prostate cancer we see today will enable us to offer personalized medicine to our patients tomorrow.
References
- 1.van der Poel H, Klotz L, Andriole G, Azzouzi AR, Bjartell A, Cussenot O, Hamdy F, Graefen M, Palma P, Rivera AR, Stief CG (2015) Role of active surveillance and focal therapy in low and intermediate risk prostate cancer. doi: 10.1007/s00345-015-1603-7
- 2.Lellig K, Gratzke C, Kretschmer A, Stief CG (2015) Final pathohistology after radical prostatectomy in patients eligible for active surveillance (AS). doi: 10.1007/s00345-015-1604-6
- 3.Billing A, Buchner A, Stief CG, Roosen A (2015) Preoperative mp-MRI of the prostate provides little information about staging of prostate carcinoma in daily clinical practice. doi: 10.1007/s00345-014-1448-5
- 4.Renard-Penna R, Cancel-Tassin G, Comperat E, Roupret M, Mozer P, Cussenot O (2015) Functional magnetic resonance imaging and molecular pathology at the crossroad of the management of early prostate cancer. doi: 10.1007/s00345-015-1570-z
- 5.Lebdai S, Azzouzi AR, Benzaghou F, Stief CG (2015) Vascular-targeted photodynamic therapy with TOOKAD® Soluble in localized prostate cancer: standardization of the procedure. doi: 10.1007/s00345-015-1535-2
- 6.Azzouzi AR, Barret E, Bennet J, Moore C, Taneja S, Muir G, Villiers A, Colemann J, Allen C, Scherz A, Emberton M (2015) TOOKAD® Soluble focal therapy: pooled analysis of three phase II studies assessing the minimally invasive ablation of localized prostate cancer. doi: 10.1007/s00345-015-1505-8
- 7.Shah TT, Kasivivanathan V, Freeman A, Emberton M, Asmed HU (2015) Histological outcomes after focal high intensity focused ultrasound and cryotherapy. doi: 10.1007/s00345-015-1561-0
- 8.Lebdai S, Villers A, Barret E, Nedelcu C, Bigot P, Azzouzi AR (2015) Feasibility, safety and efficacy of salvage radical prostatectomy after TOOKAD soluble focal treatment for localized prostate cancer. doi: 10.1007/s00345-015-1493-8
- 9.Karl A, Buchner A, Tympner C, Kirchner T, Ganswindt U, Belka C, Ganzer R, Burger M, Eder F, Hofstetter F, Schilling D, Sievert KD, Stenzel A, Scharpf M, Fend F, vom Dorp F, Rübben H, Schmidt K, Porres-Knoblauch D, Heidenreich A, Handgarter B, Knüchel-Clarke R, Rogenhofer M, Wullich B, Hautmann A, Compoj E, Pycha A, Hanspeter E, Pehrke D, Sauter G, Graefen M, Stief CG, Haese A (2015) The natural course of pT2 prostate cancer with positive surgical margin: predicting biochemical recurrence. doi: 10.1007/s00345-015-1510-y