World Journal of Urology

, Volume 32, Issue 4, pp 905–909

Peri-procedural povidone-iodine rectal preparation reduces microorganism counts and infectious complications following ultrasound-guided needle biopsy of the prostate

  • Justin R. Gyorfi
  • Christopher Otteni
  • Kevin Brown
  • Amar Patel
  • Kathleen Lehman
  • Brett E. Phillips
  • Kalyan Dewan
  • Girish Kirimanjeswara
  • Jay D. Raman
Original Article

DOI: 10.1007/s00345-014-1291-8

Cite this article as:
Gyorfi, J.R., Otteni, C., Brown, K. et al. World J Urol (2014) 32: 905. doi:10.1007/s00345-014-1291-8

Abstract

Purpose

The purpose of the study was to evaluate whether a peri-procedural povidone-iodine rectal preparation (PIRP) prior to transrectal ultrasound-guided prostate needle biopsy (TRUS PNB) can reduce microorganism colony counts and infectious complications.

Methods

Our institutional TRUS PNB database was reviewed to identify infectious post-biopsy complications (defined as fever >38.5 °C with positive culture). The last 570 biopsy patients were divided into those administered only preoperative oral and/or parenteral antibiotics (n = 456; chronologically cohorts A–D) versus men receiving peri-procedural PIRP in conjunction with standard preoperative antibiotics (n = 114; cohort E). Rectal cultures were obtained in the PIRP cohort to quantify changes in microorganism colony counts.

Results

Mean baseline PSA for patients was 11.6 ng/ml, 63 % were undergoing an initial biopsy, and 17 % had documented use of antibiotic therapy within the previous 6 months. A reduction in infectious complications was observed when comparing the conventional antibiotic (cohorts A–D) versus PIRP (cohort E) group (1.8 vs. 0 %), with the largest magnitude of decline occurring in the concurrent contemporary cohorts (cohort D—5.3 % vs. cohort E—0 %, p = 0.03). Rectal cultures obtained in 92 men before and after PIRP administration noted a 97 % reduction in microorganism colonies (2.1 × 105 vs. 6.3 × 103 CFU/ml, p < 0.001). No adverse reactions to the PIRP were reported by patients 7 days post-biopsy.

Conclusions

Peri-procedural PIRP decreased microorganism colony counts and effectively reduced infectious complications following TRUS PNB. This safe, cheap, and simple strategy may be a reasonable alternative to systemic or targeted antibiotic therapy to reduce post-biopsy infections.

Keywords

Prostate biopsy Sepsis Infection 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Justin R. Gyorfi
    • 1
  • Christopher Otteni
    • 1
  • Kevin Brown
    • 1
  • Amar Patel
    • 1
  • Kathleen Lehman
    • 1
  • Brett E. Phillips
    • 2
  • Kalyan Dewan
    • 3
  • Girish Kirimanjeswara
    • 3
  • Jay D. Raman
    • 1
  1. 1.Division of UrologyPenn State Milton S. Hershey Medical CenterHersheyUSA
  2. 2.Department of SurgeryPenn State Milton S. Hershey Medical CenterHersheyUSA
  3. 3.Department of Veterinary and Biomedical SciencePenn State UniversityUniversity ParkUSA

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