World Journal of Urology

, Volume 32, Issue 6, pp 1411–1416

Matched comparison of outcomes following open and minimally invasive radical prostatectomy for high-risk patients

  • Jonas Busch
  • Ahmed Magheli
  • Natalia Leva
  • Stefan Hinz
  • Michelle Ferrari
  • Frank Friedersdorff
  • Tom Florian Fuller
  • Kurt Miller
  • Mark L. Gonzalgo
Original Article

DOI: 10.1007/s00345-014-1270-0

Cite this article as:
Busch, J., Magheli, A., Leva, N. et al. World J Urol (2014) 32: 1411. doi:10.1007/s00345-014-1270-0

Abstract

Purpose

Comparative data related to the use of open and minimally invasive surgical approaches for the treatment of high-risk prostate cancer (PCa) remain limited. We determined outcomes of open radical prostatectomy (RRP), laparoscopic RP (LRP), and robot-assisted RP (RARP) in matched cohorts of patients with high-risk prostate cancer.

Materials and methods

A total of 805 patients with high-risk PCa [prostate-specific antigen (PSA) >20 ng/mL, Gleason score ≥8, or clinical stage ≥cT2c] were identified. A total of 407 RRP cases were propensity score (PS) matched 1:1 to 398 LRP or RARP cases to yield 3 cohorts (RARP, LRP, and RRP) of 110 patients each for analysis. PS matching variables included the following: age, clinical stage, preoperative PSA, biopsy Gleason score, surgeon experience, and nerve-sparing technique. Overall survival (OS) and recurrence-free survival (RFS) were compared with log-rank test. RFS predictor analysis was calculated within Cox regression models.

Results

Pathological Gleason scores <7, =7, and >7 were found in 3.3, 50.9, and 45.8 % of patients. There were no statistically significant differences for pathological stage and positive surgical margins between surgical techniques. Mean 3-year RFS was 41.4, 77.9, and 54.1 %, for RARP, LRP, and RRP, respectively (p < 0.0001 for RARP vs. LRP). There were no significant differences for mean estimated 3-year OS for patients treated with RARP, LRP, or RRP (95.4, 98.1, and 100 %).

Conclusions

RARP demonstrated similar oncologic outcomes compared to RRP and LRP in a PS-matched cohort of patients with high-risk prostate cancer.

Keywords

Prostate cancer Prostatectomy Laparoscopy Robotic surgery Oncologic outcome Propensity score matching High risk 

Abbreviations

RP

Radical prostatectomy

RARP

Robot-assisted laparoscopic RP

MIRP

Minimally invasive RP

RRP

Retropubic RP

PS

Propensity score

BMI

Body mass index

PSA

Prostate-specific antigen

OS

Overall survival

RFS

Recurrence-free survival

EBRT

External beam radiation therapy

ADT

Androgen deprivation therapy

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Jonas Busch
    • 1
  • Ahmed Magheli
    • 1
  • Natalia Leva
    • 2
  • Stefan Hinz
    • 1
  • Michelle Ferrari
    • 2
  • Frank Friedersdorff
    • 1
  • Tom Florian Fuller
    • 1
  • Kurt Miller
    • 1
  • Mark L. Gonzalgo
    • 3
  1. 1.Department of UrologyCharité University Medicine BerlinBerlinGermany
  2. 2.Department of UrologyStanford University School of MedicineStanfordUSA
  3. 3.Department of UrologyUniversity of Miami Miller School of MedicineMiamiUSA

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