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World Journal of Urology

, Volume 31, Issue 4, pp 977–982 | Cite as

The use of mannitol in partial and live donor nephrectomy: an international survey

  • M. Cosentino
  • A. Breda
  • F. Sanguedolce
  • J. Landman
  • J.-U. Stolzenburg
  • P. Verze
  • J. Rassweiler
  • H. Van Poppel
  • H. C. Klingler
  • G. Janetschek
  • A. Celia
  • F. J. Kim
  • G. Thalmann
  • U. Nagele
  • A. Mogorovich
  • C. Bolenz
  • T. Knoll
  • F. Porpiglia
  • M. Alvarez-Maestro
  • F. Francesca
  • F. Deho
  • S. Eggener
  • C. Abbou
  • M. V. Meng
  • M. Aron
  • P. Laguna
  • D. Mladenov
  • A. D’Addessi
  • P. Bove
  • R. Schiavina
  • O. De Cobelli
  • A. S. Merseburger
  • O. Dalpiaz
  • F. C. H. D’Ancona
  • T. J. Polascik
  • R. Muschter
  • T. J. Leppert
  • H. Villavicencio
Original Article

Abstract

Purpose

Animal studies have shown the potential benefits of mannitol as renoprotective during warm ischemia; it may have antioxidant and anti-inflammatory properties and is sometimes used during partial nephrectomy (PN) and live donor nephrectomy (LDN). Despite this, a prospective study on mannitol has never been performed. The aim of this study is to document patterns of mannitol use during PN and LDN.

Materials and methods

A survey on the use of mannitol during PN and LDN was sent to 92 high surgical volume urological centers. Questions included use of mannitol, indications for use, physician responsible for administration, dosage, timing and other renoprotective measures.

Results

Mannitol was used in 78 and 64 % of centers performing PN and LDN, respectively. The indication for use was as antioxidant (21 %), as diuretic (5 %) and as a combination of the two (74 %). For PN, the most common dosages were 12.5 g (30 %) and 25 g (49 %). For LDN, the most common doses were 12.5 g (36.3 %) and 25 g (63.7 %). Overall, 83 % of centers utilized mannitol, and two (percent or centers??) utilized furosemide for renoprotection.

Conclusions

A large majority of high-volume centers performing PN and LDN use mannitol for renoprotection. Since there are no data proving its value nor standardized indication and usage, this survey may provide information for a randomized prospective study.

Keywords

Mannitol Live donor nephrectomy Partial nephrectomy Renoprotective agent Diuretics 

Notes

Acknowledgments

To, Guazzoni G. (Department of Urology, San Raffaele Hospital, Milan Italy), Schips L. (Department of Urology, S.Pio da Pietrelcina Hospital, Vasto, Italy), Harper J (University of Washington Seattle, USA), Romanò A.L. (Department of Urology, Ospedale Luigi Sacco, Milan, Italy), Chun F.K. (Department of Urology, University of Hamburg, Germany), Sulser T. (Clinic for Urology, University Hospital, Zurich, Switzerland), Klinkl M. (Department of Urology, Medical University Vienna, Vienna, Austria), Kavoussi L. (Long Island, NY, USA), Joyce A. (St James’ University Hospital, Leeds, UK), Lucan M. (Clinical Institute of Urology and Renal Transplantation Cluj- Napoca, Romania), Leike S. (Klink und Poliklinik für Urologie Dresden, Germany) and Porena M. (Department of Medical Surgical Specialties and Public Health, Section of Urology and Andrology, Università di Perugia, Italy), Sabaté S. and Vernetta D. (Department of Anaesthesiology, Fundaciò Puigvert, Barcelona, Spain for their contribution to this survey.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • M. Cosentino
    • 1
  • A. Breda
    • 1
  • F. Sanguedolce
    • 1
  • J. Landman
    • 2
  • J.-U. Stolzenburg
    • 3
  • P. Verze
    • 4
  • J. Rassweiler
    • 5
  • H. Van Poppel
    • 6
  • H. C. Klingler
    • 7
  • G. Janetschek
    • 8
  • A. Celia
    • 9
  • F. J. Kim
    • 10
  • G. Thalmann
    • 11
  • U. Nagele
    • 12
  • A. Mogorovich
    • 13
  • C. Bolenz
    • 14
  • T. Knoll
    • 15
  • F. Porpiglia
    • 16
  • M. Alvarez-Maestro
    • 17
  • F. Francesca
    • 18
  • F. Deho
    • 19
  • S. Eggener
    • 20
  • C. Abbou
    • 21
  • M. V. Meng
    • 22
  • M. Aron
    • 23
  • P. Laguna
    • 24
  • D. Mladenov
    • 25
  • A. D’Addessi
    • 26
  • P. Bove
    • 27
  • R. Schiavina
    • 28
  • O. De Cobelli
    • 29
  • A. S. Merseburger
    • 30
  • O. Dalpiaz
    • 31
  • F. C. H. D’Ancona
    • 32
  • T. J. Polascik
    • 33
  • R. Muschter
    • 34
  • T. J. Leppert
    • 35
  • H. Villavicencio
    • 1
  1. 1.Department of Urology, Fundació PuigvertUniversitat Autònoma de BarcelonaCerdanyola del VallèsSpain
  2. 2.Department of UrologyColumbia UniversityNew York CityUSA
  3. 3.Department of UrologyUniversity LeipzigLeipzigGermany
  4. 4.Department of UrologyUniversity Federico II of NaplesNaplesItaly
  5. 5.SLK Kliniken Urology DepartmentHeidelberg UniversityHeilbronnGermany
  6. 6.Department of UrologyUniversity Hospitals LeuvenLeuvenBelgium
  7. 7.Department of UrologyMedical University of ViennaViennaAustria
  8. 8.Department of UrologyParacelsus Medical University SalzburgSalzburgAustria
  9. 9.Department of UrologySan Bassiano HospitalBassano del GrappaItaly
  10. 10.Denver Health Medical Center, Tony Grampsas Cancer CenterUniversity of Colorado Health Sciences CenterBoulderUSA
  11. 11.Department of UrologyUniversity HospitalBerneSwitzerland
  12. 12.General Hospital Hall in TyrolEisenstadtAustria
  13. 13.Department of UrologyUniversità di PisaPisaItaly
  14. 14.Mannheim Medical CenterUniversity of HeidelbergMannheimGermany
  15. 15.Klinikum Sindelfen-BoblingenUniversity of TueblingenTueblingenGermany
  16. 16.Department of UrologySan Luigi HospitalOrbassano, TurinItaly
  17. 17.Department of UrologyHospital Universitario Infanta SofiaMadridSpain
  18. 18.U.O. Urologia 2Azienda Ospedaliera Universitaria PisanaPisanaItaly
  19. 19.Department of UrologyOspedali Riuniti BergamoBergamoItaly
  20. 20.University of ChicagoChicagoUSA
  21. 21.Department of Urology CHU Henri MondorCréteilFrance
  22. 22.Department of UrologyUCSFSan FranciscoUSA
  23. 23.University of Southern CaliforniaLos AngelesUSA
  24. 24.AMC University HospitalAmsterdamThe Netherlands
  25. 25.Clinic of UrologyMedical UniversitySofiaBulgaria
  26. 26.Department of UrologyUniversità Cattolica del Sacro CuoreRomeItaly
  27. 27.Department of UrologyUniversità Tor VegataRomeItaly
  28. 28.Department of UrologyAlma Mater Studiorum Università di BolognaBolognaItaly
  29. 29.Department of UrologyEuropean Institute of OncologyMilanItaly
  30. 30.Hannover Medical SchoolHannoverGermany
  31. 31.Department of UrologyUniversity of GrazGrazAustria
  32. 32.Department of UrologyUniversity Hospital NijmegenNijmegenThe Netherlands
  33. 33.Duke UniversityDurhamUSA
  34. 34.Department of UrologyDiakoniekrankenhaus Academic Teaching HospitalRotenburgGermany
  35. 35.Department of UrologyStanford UniversityStanfordUSA

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