World Journal of Urology

, Volume 31, Issue 3, pp 665–671 | Cite as

The effects of dutasteride and finasteride on BPH-related hospitalization, surgery and prostate cancer diagnosis: a record-linkage analysis

  • Luca Cindolo
  • Caterina Fanizza
  • Marilena Romero
  • Luisella Pirozzi
  • Riccardo Autorino
  • Francesco Berardinelli
  • Luigi Schips
Original Article



To investigate differences in the risk of benign prostatic hyperplasia (BPH)-related hospitalization, for surgical and non-surgical reasons, and of new prostate cancer (PCa) diagnosis between patients using finasteride or dutasteride.


A retrospective cohort study was conducted using data from record linkage of administrative databases (pharmaceutical prescription data, hospital discharge records, Italian population registry). Men aged ≥40 years old who had received a prescription for at least 10 packs/year between January 1, 2004 and December 31, 2004 were included and followed for 5 years.

The association of the outcomes was assessed using a multiple Cox proportional hazard model. Propensity score-matched analysis and a 5–1, greedy 1:1 matching algorithm were performed.


8,132 patients were identified. Overall incidence rates of BPH hospitalization and BPH-related surgery were 21.05 (95 % CI 19.52–22.71) and 20.97 (95 % CI 19.45–22.61) per 1,000 person-years, respectively. In the dutasteride group compared with finasteride group, the incidence rate of both events was statistically significant lower: 16.07 versus 21.76 for BPH hospitalization and 15.91 versus 21.69 for BPH-related surgery. The incidence rate of new PCa was also lower for the dutasteride group [8.34 (95 % CI 5.96–11.68) vs. 10.25 (95 % CI 9.15–11.49)]. Dutasteride was associated with a reduction in BPH-related hospitalizations (HR 0.75, 95 % CI 0.58–0.98 and 0.58–0.98 for surgical and non-surgical reasons). The matched analysis confirmed the risk reduction with dutasteride for BPH-related surgery.


These findings suggest that the clinical effects of dutasteride and finasteride might be different. Patients treated with dutasteride seem to be less likely to experience BPH-related hospitalization. Comparative studies are needed to confirm these results.


Benign prostatic hyperplasia (BPH) Dutasteride Finasteride Epidemiology Medical record linkage 



This study was financially supported by an unconditional grant from GlaxoSmithKline.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Luca Cindolo
    • 1
    • 4
  • Caterina Fanizza
    • 2
  • Marilena Romero
    • 2
  • Luisella Pirozzi
    • 2
  • Riccardo Autorino
    • 3
  • Francesco Berardinelli
    • 4
  • Luigi Schips
    • 4
  1. 1.Department of UrologyS.Pio Da Pietrelcina HospitalVastoItaly
  2. 2.Department of Clinical Pharmacology and EpidemiologyConsorzio Mario Negri SudSanta Maria ImbaroItaly
  3. 3.Urology UnitSecond University of NaplesNaplesItaly
  4. 4.Department of UrologyS.Pio Da Pietrelcina HospitalVastoItaly

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