World Journal of Urology

, Volume 31, Issue 6, pp 1389–1394

Prevalence of the human papillomavirus (HPV) expression of the inner prepuce in asymptomatic boys and men

  • Gerald Klinglmair
  • Renate Pichler
  • Bettina Zelger
  • Hasan Serkan Dogan
  • Tanja Becker
  • Johannes Esterbauer
  • Markus Riccabona
  • Wolfgang Loidl
  • Wolfgang Horninger
  • Josef Oswald
Original Article

Abstract

Objective

To investigate the prevalence of high-risk (HR) and low-risk (LR) human papillomavirus (HPV) in prepuces of boys and men without any HPV related lesions.

Patients and methods

Between 2009 and 2011, a total collective of 250 boys and men were investigated in this prospective study. The samples were subdivided into 3 groups regarding their age, consisting of 125 (50 %) children (0–10 years), 38 (15.2 %) adolescents (11–20 years) and 87 (34.8 %) adults (>20 years). In situ hybridization (ISH) was performed to detect HR and LR virus types within the epithelium, followed by microscopic interpretation and determination between episomal and integrative signal pattern.

Results

Our results revealed high levels of HPV concentration (HR and LR) in all age groups: HR versus LR positivity was seen in 45.5 versus 35 % (children), 60.6 versus 63.6 % (adolescents) and 58.3 versus 48.6 % (adults). The topmost rate of HR (59.8 %)- and LR (50.6 %)-positive probes was found in the group with high estimated sexual activity (>14 years).

Conclusion

Concerning the high prevalence of male HPV infection even in children, indicating non-sexual transmission pathways, inclusion of boys in the vaccination program seems to be required reducing their burden of HPV related disease.

Keywords

HPV Circumcision STD Prepuce Vaccination 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Gerald Klinglmair
    • 1
  • Renate Pichler
    • 1
  • Bettina Zelger
    • 2
  • Hasan Serkan Dogan
    • 3
  • Tanja Becker
    • 4
  • Johannes Esterbauer
    • 5
  • Markus Riccabona
    • 4
  • Wolfgang Loidl
    • 5
  • Wolfgang Horninger
    • 1
  • Josef Oswald
    • 1
  1. 1.Department of UrologyMedical University of InnsbruckInnsbruckAustria
  2. 2.Department of PathologyMedical University of InnsbruckInnsbruckAustria
  3. 3.Department of Urology, Faculty of MedicineUludag UniversityGorukle, BursaTurkey
  4. 4.Department of Pediatric UrologySt. Vincent’s HospitalLinzAustria
  5. 5.Department of UrologySt. Vincent’s HospitalLinzAustria

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