World Journal of Urology

, Volume 29, Issue 4, pp 541–546

The influence of age on bioavailable and free testosterone is independent of body mass index and glucose levels

  • Graziele Halmenschlager
  • Ernani Luis Rhoden
  • Charles Edison Riedner
Original Article

Abstract

Purpose

To evaluate the influence of age on serum levels of total testosterone (TT), bioavailable testosterone (BT), free testosterone (FT), and sex-hormone binding globulin (SHBG), considering the presence of fasting blood glucose levels and body mass index (BMI) in a selected male population.

Methods

A total of 428 men were analyzed. Anthropometry was taken from all, considering BMI as general obesity indicative variable. Fasting blood samples were drawn for determination of plasma glucose levels and serum levels of albumin, TT, and SHBG. The values of BT and FT were calculated from TT, SHBG, and albumin, by Vermeulen’s equation. Statistical significance was set at P ≤ 0.05.

Results

Age was negatively correlated to BT (r = −0.301; P < 0.001) and FT (r = −0.273; P < 0.001), but not to TT levels (r = 0.002, P = 0.974). Age was positively correlated to SHBG (r = 0.376; P < 0.001). Age was independently associated with the occurrence of high SHBG levels (OR = 1.07, 95%CI = 1.05–1.10, P < 0.001) and of low BT (OR = 1.04, 95%CI = 1.02–1.07, P < 0.001) and FT levels (OR = 1.05, 95%CI = 1.03–1.08, P < 0.001), but not with low levels of TT (P = 0.08).

Conclusions

Age was significantly associated to high levels of SHBG and to low levels of BT and FT, without significant association to TT. This pattern was independent of BMI and glucose levels.

Keywords

Aging Androgens Blood glucose Body mass index 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Graziele Halmenschlager
    • 1
  • Ernani Luis Rhoden
    • 2
    • 3
    • 4
  • Charles Edison Riedner
    • 5
  1. 1.Curso de Pós-Graduação em Ciências da SaúdeUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)Porto AlegreBrazil
  2. 2.Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)Porto AlegreBrazil
  3. 3.CNPq-Conselho Nacional de Pesquisa, Researcher Level 2Porto AlegreBrazil
  4. 4.Médico Hospital Moinhos de VentoPorto AlegreBrazil
  5. 5.Urology Unit of Military Hospital of Porto AlegrePorto AlegreBrazil

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