World Journal of Urology

, Volume 29, Issue 3, pp 349–354 | Cite as

Tubulocystic renal carcinoma: a clinical perspective

  • Milan Hora
  • Tomáš Ürge
  • Viktor Eret
  • Petr Stránský
  • Jiří Klečka
  • Boris Kreuzberg
  • Jiří Ferda
  • Luboš Hyršl
  • Ján Breza
  • Petra Holečková
  • Michal Mego
  • Michal Michal
  • Fredrik Petersson
  • Ondřej Hes
Original Article

Abstract

Introduction

Tubulocystic renal carcinoma (TCRC) is a recently described neoplastic entity. To date, clinicopathological features on less than hundred cases of these rare tumours have been characterized exclusively in the pathological literature. Herein, we present five additional cases emphasizing clinical aspects on these rare renal neoplasms.

Material and method

Cases diagnosed as TCRC were retrieved and reviewed from the routine and consultation files of the Pilsen tumour registry comprising over 20,000 cases of renal tumours.

Results

All patients were men, mean age 56 years (range 29–70). Features on computed tomography (CT) were in two cases Bosniak III, one IV and two were solid tumours. In four patients, nephrectomy was performed, and one patient underwent resection. At the time of surgery, two patients had metastases. In one case, both primary tumour and metastases were active on FDG positron emission tomography (PET)/CT. Both patients with metastatic disease were treated with sunitinib with partial response. One patient died 26 months postoperatively and the other patient is alive 5 months after surgery. Three patients with localized tumours are without evidence of disease 31, 28 and 7 months after surgery. In one case, the resected tumour was histologically combined with a papillary renal cell carcinoma (PRCC).

Conclusion

TCRC occurs predominantly in men with a wide age range. TCRC frequently displays a cystic component which may render a radiological classification of Bosniak III or IV. FDG PET/CT is helpful in the detection of metastases. TCRC has definitive malignant potential. Our findings support a possible relationship to PRCC. The tyrosine kinase inhibitor sunitinib may be used a therapeutical agent with partial response and temporary effect.

Keywords

Carcinoma Renal cell (tubulocystic) Computed tomography Positron emission tomography Nephrectomy Angiogenesis inhibitor (sunitinib) 

Notes

Acknowledgments

The work was supported by the Czech government research project MSM 0021620819.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Milan Hora
    • 1
  • Tomáš Ürge
    • 1
  • Viktor Eret
    • 1
  • Petr Stránský
    • 1
  • Jiří Klečka
    • 1
  • Boris Kreuzberg
    • 2
  • Jiří Ferda
    • 2
  • Luboš Hyršl
    • 3
  • Ján Breza
    • 4
  • Petra Holečková
    • 5
  • Michal Mego
    • 6
  • Michal Michal
    • 7
  • Fredrik Petersson
    • 7
    • 8
  • Ondřej Hes
    • 7
  1. 1.Department of UrologyCharles University HospitalPlzeňCzech Republic
  2. 2.Department of RadiologyCharles University HospitalPlzeňCzech Republic
  3. 3.Department of UrologyHospital KladnoKladnoCzech Republic
  4. 4.Department of UrologyL. Dérer’s University HospitalBratislavaSlovak Republic
  5. 5.Department of OncologyUniversity Hospital BulovkaPragueCzech Republic
  6. 6.2nd Department of Medical OncologyComenius University, School of MedicineBratislavaSlovakia
  7. 7.Department of PathologyCharles University HospitalPlzeňCzech Republic
  8. 8.Department of PathologyNational University Health SystemSingaporeSingapore

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