World Journal of Urology

, Volume 28, Issue 3, pp 343–351

Management of sunitinib-related adverse events: an evidence- and expert-based consensus approach

  • Viktor Grünwald
  • Daniel Kalanovic
  • Axel S. Merseburger
Topic Paper

DOI: 10.1007/s00345-010-0565-z

Cite this article as:
Grünwald, V., Kalanovic, D. & Merseburger, A.S. World J Urol (2010) 28: 343. doi:10.1007/s00345-010-0565-z



The advance of medical treatment in renal cell carcinoma (RCC) has fostered the development of diverse continuous oral therapies with tyrosine kinase inhibitors (TKI), among these sunitinib remains the mainstay of therapy for most of the patients. Based on its clinical activity, disease control over a period of 11 months can be expected with sunitinib treatment. Given this prolonged period of exposure to sunitinib, adverse events tend to reoccur and can possibly decrease the quality of life in our patients. Hence, development of modalities to detect, treat and cope with such adverse events has become a major focus for physicians and patients. Today, numerous publications address these questions and offer advice from experienced centers. However, these reviews summarize single or oligo-center experiences.

Methods and Results

Our approach is based (1) on an extensive review and analysis of available evidence from literature and (2) a structured consensus survey among 12 German experts in the field who treated at least 30 patients each with a TKI.


Derived from this process, this paper gives an overview on Sunitinib therapy management recommendations deducted from published evidence and consensus agreement among experts.


Sunitinib Adverse events Management Survey 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Viktor Grünwald
    • 1
  • Daniel Kalanovic
    • 2
  • Axel S. Merseburger
    • 3
  1. 1.Clinic for Hematology, Hemostaseology, Oncology and Stem Cell TransplantationHannover Medical SchoolHannoverGermany
  2. 2.Pfizer Pharma GmbHBerlinGermany
  3. 3.Department of Urology and Urologic OncologyHannover Medical SchoolHannoverGermany

Personalised recommendations