World Journal of Urology

, 27:117 | Cite as

Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury

  • Murat Bozlu
  • Deniz Acar
  • Selahittin Cayan
  • Savas Aktas
  • Ahmet Tunckiran
Original Article



Trapidil is an antianginal compound with a broad spectrum of pharmacological activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. We evaluated the effect of trapidil on the long-term histologic damage in testicular ischemia-reperfusion injury.


Adult male Wistar rats were divided into three groups of six rats each. One group underwent 2 h of testicular torsion; one received pretreatment with trapidil before detorsion; and one group underwent sham operation. All rats underwent bilateral orchiectomy 60 days after the experiment. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were determined by histological examination of each testis.


Testicular torsion–detorsion caused a significant decrease in the mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score in the ipsilateral testes, but not in the contralateral testes. The animals treated with trapidil had a significant increase in these histological parameters as compared to the torsion–detorsion group.


Trapidil administration before reperfusion may have the potential to decrease the long-term histologic damage that occurs after experimental testicular torsion. Trapidil is used as an antianginal drug and additional clinical studies are required to elucidate the protective role of trapidil in patients with testicular torsion.


Testis Reperfusion injury Trapidil Rats 


Conflict of interest statement

There is no conflict of interest.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Murat Bozlu
    • 1
  • Deniz Acar
    • 1
  • Selahittin Cayan
    • 1
  • Savas Aktas
    • 2
  • Ahmet Tunckiran
    • 1
  1. 1.Department of UrologyUniversity of Mersin School of MedicineMersinTurkey
  2. 2.Department of Histology/EmbryologyUniversity of Mersin School of MedicineMersinTurkey

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