World Journal of Urology

, Volume 24, Issue 6, pp 611–617

The male biological clock

Topic Paper

DOI: 10.1007/s00345-006-0130-y

Cite this article as:
Lambert, S.M., Masson, P. & Fisch, H. World J Urol (2006) 24: 611. doi:10.1007/s00345-006-0130-y


Do men have biological clocks that affect their hormone levels, fertility, and the genetic quality of their sperm? Women can no longer be viewed as solely responsible for age-related fertility and genetic problems. The effects of andropause and advanced paternal age on fertility and offspring are still under investigation. Further research is needed to fully characterize the associated risks and to treat the underlying abnormalities. A better understanding of the cellular and biochemical mechanisms of “gonadal” aging is important in order to determine safe, effective ways to delay this process and “rewind” the male biological clock. The benefits may include decreasing the potential for adverse genetic consequences in offspring, improvement in the sexual and reproductive health of aging males, and increase a woman’s chance of having healthy children by correcting defects in the male reproductive system.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Columbia University College of Physicians and Surgeons, Department of UrologyColumbia University Medical Center of New York Presbyterian HospitalNew YorkUSA

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