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World Journal of Urology

, Volume 24, Issue 4, pp 418–422 | Cite as

Clinical decisions for treatment of different staged bladder cancer based on multitarget fluorescence in situ hybridization assays?

  • F. Steffen KrauseEmail author
  • Anita Rauch
  • Karl M. Schrott
  • Dirk G. Engehausen
Original Article

Abstract

Non-invasive methods for detecting genetic alterations of bladder cancer are increasingly becoming the focus of attention as diagnostic tools. The fluorescence in situ hybridization we performed to detect genetic alterations of chromosomes 3, 7, 9p21, and 17 (UroVysion Test) showed very high sensitivity, higher even than cytology, in detecting bladder tumors of varying differentiation (pTa-pT4). The use of this test in everyday clinical urology can be a very useful decision aid in treating problem cases. A pT1G3 bladder carcinoma in the presence of multichromosomal alterations should be treated as a muscle-invasive pT2 tumor. Other superficial bladder tumors (pTaGI-III, pT1GI-II) with negative histopathology in follow-up and positive FISH analysis with the UroVysion Test should have bladder mapping performed again. Although FISH analysis is currently the most sensitive marker for bladder tumors, the elaborate handling, the cost of the DNA probes and the laboratory equipment required, limit the use of this method in the urologist’s everyday routine.

Keywords

Bladder cancer Multitarget FISH Diagnostical tool 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • F. Steffen Krause
    • 1
    Email author
  • Anita Rauch
    • 2
  • Karl M. Schrott
    • 1
  • Dirk G. Engehausen
    • 1
  1. 1.Department of UrologyFriedrich-Alexander UniversityErlangen-NurembergGermany
  2. 2.Institute of Human GeneticsFriedrich-Alexander University Erlangen-NurembergGermany

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