World Journal of Urology

, Volume 23, Issue 5, pp 356–360 | Cite as

Efficacy of 1-day prophylaxis medication with fluoroquinolone for prostate biopsy

  • Katsumi Shigemura
  • Kazushi Tanaka
  • Mitsuru Yasuda
  • Satoshi Ishihara
  • Tetsuro Muratani
  • Takashi Deguchi
  • Tetsuro Matsumoto
  • Sadao Kamidono
  • Yuzo Nakano
  • Soichi Arakawa
  • Masato Fujisawa
Original Article

Abstract

A prospective, randomized trial in which 236 patients received oral levofloxacin, either at 600 mg/day for 1 day (n=124) or 300 mg/day for 3 days (n=112). Urinalysis, plasma white blood cell count (WBC) (per mm3), and C reactive protein (CRP) (mg/dl) levels were checked before prostate biopsy (PBX), on the day after PBX, and on the seventh day after PBX. Two patients (1.61%) who received 600 mg for 1 day and 2 patients (1.79%) who received 300 mg for 3 days had febrile infectious complications. There was no statistically significant difference between levofloxacin at 600 mg for 1 day and levofloxacin at 300 mg for 3 days regarding the elevation of WBC and CRP. We can perform PBX safely with levofloxacin at 600 mg for 1 day as prophylaxis and recommend this method from the point of view of the decrease of antibiotic-resistant strains.

Keywords

Prostate biopsy Prophylaxis Infectious complication Levofloxacin 1 day 

References

  1. 1.
    Aron M, Rajeev TP, Gupta NP (2000) Antibiotic prophylaxis for transrectal needle biopsy of the prostate: a randomized controlled study. BJU Int 85:682–685CrossRefPubMedGoogle Scholar
  2. 2.
    Bishop D, Oliver J (1977) A study of transrectal aspiration biopsies of the prostate, with particular regard to prognostic evaluation. J Urol 117:313–315PubMedGoogle Scholar
  3. 3.
    Brewster SF, MacGowan AP, Gingell JC (1995) Antimicrobial prophylaxis for transrectal prostatic biopsy: a prospective randomized trial of cefuroxime versus piperacillin/tazobactam. Br J Urol 76:351–354PubMedCrossRefGoogle Scholar
  4. 4.
    Carey JM, Korman HJ (2001) Transrectal ultrasound guided biopsy of the prostate. Do enemas decrease clinically significant complications? J Urol 166:82–85CrossRefPubMedGoogle Scholar
  5. 5.
    Onder AU, Yaycioglu O, Ataus S, Gul U, Demirkesen O, Yalcin V, Solok V (2003) Transition zone biopsy and prediction of extraprostatic extension at radical prostatectomy. Int J Urol 10:302–308CrossRefPubMedGoogle Scholar
  6. 6.
    Cormio L, Berardi B, Callea A, Fiorentino N, Sblendorio D, Zizzi V, Traficante A (2002) Antimicrobial prophylaxis for transrectal prostatic biopsy: a prospective study of ciprofloxacin vs piperacillin/tazobactam. BJU Int 90:700–702CrossRefPubMedGoogle Scholar
  7. 7.
    Crawford ED, Haynes AL Jr, Story MW, Borden TA (1982) Prevention of urinary tract infection and sepsis following transrectal prostatic biopsy. J Urol 127:449–451PubMedGoogle Scholar
  8. 8.
    Davis R, Bryson HM (1994) Levofloxacin. A review of its antibacterial activity, pharmacokinetics, and therapeutic efficacy. Drugs 48:132CrossRefGoogle Scholar
  9. 9.
    Desmond PM, Clark J, Thompson IM, Zeidman EJ, Mueller EJ (1993) Morbidity with contemporary prostate biopsy. J Urol 150:1425–1426PubMedGoogle Scholar
  10. 10.
    Drusano GL, Preston SL, Van Guilder M (2000) A population pharmacokinetic analysis of the penetration of the prostate by levofloxacin. Antimicrob Agents Chemother 44:2046–2051CrossRefPubMedGoogle Scholar
  11. 11.
    Fournier G, Valeri A, Mangin P, Cussenot O (2004) Prostate cancer: diagnosis and staging. Ann Urol (Paris) 38:207–224Google Scholar
  12. 12.
    Fujimoto N, Harada S, Sato H, Akasaka S, Nomura M, Yamada Y, Ueno Y, Matsumoto T (2004) Screening for prostate cancer in Yahata, Kitakyushu. J UOEH 26:239–244PubMedGoogle Scholar
  13. 13.
    Griffith BC, Morey AF, Ali-Khan MM, Canby-Hagino E, Foley JP, Rozanski TA (2002) Single dose levofloxacin prophylaxis for prostate biopsy in patients at low risk. J Urol 168:1021–1023CrossRefPubMedGoogle Scholar
  14. 14.
    Isen K, Kupeli B, Sinik Z, Sozen S, Bozkirli I (1999) Antibiotic prophylaxis for transrectal biopsy of the prostate: a prospective randomized study of the prophylactic use of single dose oral fluoroquinolone versus trimethoprim-sulfamethoxazole. Int Urol Nephrol 31:491–495CrossRefPubMedGoogle Scholar
  15. 15.
    Kapoor DA, Klimberg IW, Malek GH, Wegenke JD, Cox CE, Patterson AL, Graam E, Echols RM, Whalen E, Kowalsky SF (1998) Single-dose oral ciprofloxacin versus placebo for prophylaxis during transrectal prostate biopsy. Urology 52:552–558CrossRefPubMedGoogle Scholar
  16. 16.
    Larsen EH, Gasser TC, Madsen PO (1986) Antimicrobial prophylaxis in urologic surgery. Urol Clin North Am 4:591–604Google Scholar
  17. 17.
    Lindert KA, Kabalin JN, Terris MK (2000) Bacteremia and bacteriuria after transrectal ultrasound guided prostate biopsy. J Urol 164:76–80CrossRefPubMedGoogle Scholar
  18. 18.
    Onder AU, Yaycioglu O, Ataus S, Gul U, Demirkesen O, Yalcin V, Solok V (2003) Transition zone biopsy and prediction of extraprostatic extension at radical prostatectomy. Int J Urol 10:302–308CrossRefPubMedGoogle Scholar
  19. 19.
    Packer MG, Russo P, Fair WR (1984) Prophylactic antibiotics and Foley catheter use in transperineal needle biopsy of the prostate. J Urol 131:687–689PubMedGoogle Scholar
  20. 20.
    Sieber PR, Rommel FM, Agusta VE, Breslin JA, Huffnagle HW, Harpster LE (1997) Antibiotic prophylaxis in ultrasound guided transrectal prostate biopsy. J Urol 157:2199–2200CrossRefPubMedGoogle Scholar
  21. 21.
    Turner B, Warner J, Rhamy R (1980) Prostatic needle examination. South Med J 73:183–184PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Katsumi Shigemura
    • 1
  • Kazushi Tanaka
    • 1
  • Mitsuru Yasuda
    • 2
  • Satoshi Ishihara
    • 2
  • Tetsuro Muratani
    • 3
  • Takashi Deguchi
    • 2
  • Tetsuro Matsumoto
    • 3
  • Sadao Kamidono
    • 1
  • Yuzo Nakano
    • 1
  • Soichi Arakawa
    • 1
  • Masato Fujisawa
    • 1
  1. 1.Division of Urology, Department of Organs Therapeutics, Faculty of MedicineKobe University Graduate School of MedicineKobeJapan
  2. 2.Department of UrologyGifu University School of MedicineGifuJapan
  3. 3.Department of Urology, School of MedicineUniversity of Occupational and Environmental HealthKitakyushuJapan

Personalised recommendations