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Applied Physics B

, Volume 111, Issue 3, pp 359–365 | Cite as

Quantum cascade laser-based sensor for detection of exhaled and biogenic nitric oxide

  • D. Marchenko
  • J. Mandon
  • S. M. Cristescu
  • P. J. F. M. Merkus
  • F. J. M. Harren
Article

Abstract

A sensor based on a continuous wave quantum cascade laser, operating near 5.2 μm, in combination with integrated cavity output spectroscopy has been developed for simultaneous measurement of nitric oxide (NO) and carbon dioxide (CO2) traces in exhaled air. A detection limit of 0.7 parts-per-billion by volume of NO (acquisition time: 1 s) is achieved. Comparison is made with the standard chemiluminescence NO analyzer and commercial CO2 breath sampler. The QCL-based sensor is tested on healthy subjects at various exhalation flow rates (15, 50, 100 and 300 ml/s) for both online and offline sampling procedures as well as on asthmatic children (offline sampling). Possibilities for measurements of biogenic NO in vivo, i.e., NO coming from human skin tissue, are also demonstrated.

Keywords

Nitric Oxide Asthmatic Child Skin Tissue Quantum Cascade Laser Integrate Cavity Output Spectroscopy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by the GO-EFRO Ultragas, project no. 2009-010034 of province of Gelderland (The Netherlands) and EU, EU-Marie Curie fellowships EU-people-2010-IEF, project no. 275584, QCLaser Nose, the Asthma Fund grant AF 2011, project no. 3.3.11.002, and IOP-Photonics, project no. IPD100025.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • D. Marchenko
    • 1
  • J. Mandon
    • 1
  • S. M. Cristescu
    • 1
  • P. J. F. M. Merkus
    • 2
  • F. J. M. Harren
    • 1
  1. 1.Life Science Trace Gas Facility, Molecular and Laser PhysicsInstitute for Molecules and Materials, Radboud UniversityNijmegenThe Netherlands
  2. 2.Department of Pediatric PulmonologyRadboud University Nijmegen Medical CentreNijmegenThe Netherlands

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