Applied Physics B

, Volume 94, Issue 4, pp 667–672 | Cite as

Analysis of serum from type II diabetes mellitus and diabetic complication using surface-enhanced Raman spectra (SERS)

Article

Abstract

In this paper, we show surface-enhanced Raman spectra (SERS) of serums from type II diabetes mellitus and diabetic complication (coronary disease, glaucoma and cerebral infarction), and analyze the SERS through the multivariate statistical methods of principal component analysis (PCA). In particular, we find that there exist many adenines in these serums, which maybe come from DNA (RNA) damage. The relative intensity of the band at 725±2 cm−1 assigned to adenine is higher for patients than for the healthy volunteers; therefore, it can be used as an important ‘fingerprint’ in order to diagnose these diseases. It is also shown that serums from type II diabetes mellitus group, diabetic complication group and healthy volunteers group can be discriminated by PCA.

PACS

07.60 87.00 95.75Fs 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    D. Rohleder, W. Kiefer, W. Petrich, Analyst 129, 906 (2004) CrossRefADSGoogle Scholar
  2. 2.
    S. Kreisig, A. Tarazona, E. Koglin, Electrochim. Acta 42, 3335 (1997) CrossRefGoogle Scholar
  3. 3.
    A. Otto, I. Mrozek, H. Grabhom, W. Akemann, J. Phys. Condens. Matter 4, 1143 (1992) CrossRefADSGoogle Scholar
  4. 4.
    H.X. Xu, E.J. Bjerneld, M. Kall, L. Borjesson, Phys. Rev. Lett. 83, 4357 (1999) CrossRefADSGoogle Scholar
  5. 5.
    K. Kneipp, A.S. Haka, H. Kneipp, K. Badizadegan, N. Yoshizawa, C. Boone, K.E. Shafer-Peltier, J.T. Motz, R.R. Dasari, M.S. Feld, Appl. Spectrosc. 56, 150 (2002) CrossRefADSGoogle Scholar
  6. 6.
    K. Kneipp, Y. Wang, R.R. Dasari, M.S. Feld, Appl. Spectrosc. 49, 780 (1995) CrossRefADSGoogle Scholar
  7. 7.
    C. Eliasson, A. Lorén, J. Engelbrektsson, M. Josefson, J. Abrahamsson, K. Abrahamsson, Spectrochim. Acta Part A 61, 755 (2005) CrossRefGoogle Scholar
  8. 8.
    K. Kneipp, A.S. Haka, H. Kneipp, K. Badizadegan, N. Yoshizawa, C. Boone, K.E. Shafer-Peltier, J.T. Motz, R.R. Dasari, M.S. Feld, Appl. Spectrosc. 56, 150 (2002) CrossRefADSGoogle Scholar
  9. 9.
    G. Fabriciova, S. Sanchez-Cortes, J.V. Garcia-Ramos, P. Miskovsky, Biopolymers 74, 125 (2004) CrossRefGoogle Scholar
  10. 10.
    P. Miskovsky, J. Hritz, S. Sanchez-Cortes, Photochem. Photobiol. 74, 172 (2001) CrossRefGoogle Scholar
  11. 11.
    J.L. Pichardo-Molina, C. Frausto-Reyes, O. Barbosa-Garcia, R. Huerta-Franco, J.L. Gonzales-Trujillo, C.A. Ramirez-Alvarado, G. Gutierrez-Juarez, C. Medina-Gutierrez, Lasers Med. Sci. 22, 229 (2007) CrossRefGoogle Scholar
  12. 12.
    A.M.K. Enejder, T.-W. Koo, J. Oh, M. Hunter, S. Sasic, M.S. Feld, G.L. Horowitz, Opt. Lett. 27, 2004 (2002) CrossRefADSGoogle Scholar
  13. 13.
    A.J. Berger, T.-W. Koo, I. Itzkan, G. Horowitz, M.S. Feld, Appl. Opt. 38, 2916 (1999) CrossRefGoogle Scholar
  14. 14.
    C.R. Lee, S.J. Bae, M.S. Gong, K. Kim, S.W. Joo, J. Raman Spectrosc. 33, 429 (2002) CrossRefGoogle Scholar
  15. 15.
    A. Callegari, D. Tonti, M. Chergui, Nano Lett. 11, 1565 (2003) CrossRefGoogle Scholar
  16. 16.
    Z.Y. Zhang, Y.M. Xu, Sci. Chin. Ser. B 12, 595 (1991) Google Scholar
  17. 17.
    L. Dostal, R. Misselwitz, S. Laettig, J.C. Alonso, H. Welfle, Spectroscopy 17, 435 (2003) Google Scholar
  18. 18.
    D.C. Goodwin, J. Brahms, Nucleic Acids Res. 5, 835 (1978) CrossRefGoogle Scholar
  19. 19.
    R.C. Lord, N.T. Yu, J. Mol. Biol. 50, 509 (1970) CrossRefGoogle Scholar
  20. 20.
    Z.Y. Zhang, Y.M. Xu, Sci. China Ser. B 35, 437 (1992) Google Scholar
  21. 21.
    B.P. Gaber, W.L. Peticolas, Biochem. Biophys. Acta 465, 260 (1997) Google Scholar
  22. 22.
    Y.M. Xu, C.Z. Lu, Sci. China Ser. C (Life Sci.) 48, 117 (1997) Google Scholar
  23. 23.
    C.Y. She, N.D. Dinh, A.T. Tu, Biochim. Biophys. Acta 372, 345 (1974) Google Scholar
  24. 24.
    H.X. Zhao, Y.M. Xu, C.Z. Lu, Asian J. Spectrosc. 1, 71 (1997) Google Scholar
  25. 25.
    S. Raychaudhuri, J.M. Stuart, R.B. Altman, Pac. Symp. Biocomput. 5, 452 (2000) Google Scholar
  26. 26.
    M.A. Kramer, AIChE J. 37, 233 (1991) CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • H. W. Han
    • 1
  • X. L. Yan
    • 1
  • R. X. Dong
    • 1
  • G. Ban
    • 1
  • K. Li
    • 1
  1. 1.School of Physical Science and Information TechnologyLiaocheng UniversityLiaochengChina

Personalised recommendations