Current status of clinical breath analysis
- 1.8k Downloads
Clinical breath analysis remains in its infancy, despite the fact that its potential has been recognized for centuries and that blood, urine, and other bodily fluids and tissues are routinely analyzed to diagnose disease or to monitor therapy. This review discusses the present status of clinical breath analysis and suggests reasons why breath analysis has not received similar widespread clinical use. Currently, a number of marker molecules have been identified in breath that could be used to identify disease, disease progression, or to monitor therapeutic intervention and this list is expected increase dramatically since the analysis of breath is ideally suited for population-based studies in the developed and underdeveloped world. Recent advances in analytical instrumentation have suggested that the use of exhaled breath in medicine should now be re-examined. In particular, the availability of real-time, portable monitors will represent a breakthrough for clinical diagnosis. Progress in clinical breath analysis will require collaboration amongst device makers, experts in breath analysis, and clinicians.
Unable to display preview. Download preview PDF.
- 2.B.O. Jansson, B.T. Larsson, J. Lab. Clin. Med. 74, 961 (1969)Google Scholar
- 3.S. Chen, L. Zieve, V. Mahadevan, J. Lab. Clin. Med. 75, 628 (1970)Google Scholar
- 7.T.H. Risby, W. Maley, R.P. Scott, G.B. Bulkley, M. Kazui, S.S. Sehnert, K.B. Schwarz, J. Potter, E. Mezey, A.S. Klein, P. Colombani, J. Fair, W.T. Merritt, C. Beattie, M.C. Mitchell, G.M. Williams, B.A. Perler, R.T. Donham, J.F. Burdick, Surgery 115, 94 (1994)Google Scholar
- 8.K.A. Cope, Breath Biomarkers of Exposure and Disease. PhD Dissertation, Johns Hopkins University (2002)Google Scholar
- 10.A.S. Modak, 13C Breath tests: transition from research to clinical practice. In: Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring, ed. by A. Amann, D. Smith (World Scientific, Singapore, 2005) pp. 457–478Google Scholar
- 12.Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children-1999. This Official Statement of the American Thoracic Society was Adopted by the ATS Board of Directors, July 1999. Am. J. Respir. Crit. Care Med. 160, 2104 (1999)Google Scholar
- 15.J.D. Pleil, D. Kim, J.D. Prah, D.L. Ashley, S.M. Rappaport, The unique value of breath biomarkers for estimating pharmacokinetic rate conatnats and body burden from environmental exposure. In: Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring, ed. by A. Amann, D. Smith (World Scientific, Singapore, 2005) pp. 347–359Google Scholar
- 18.J.H. Gross, Mass Spectrometry A Textbook (Springer, New York, 2004)Google Scholar
- 20.D. Smith, P. Spanel, Selected ion flow tube mass spectrometry, SIFT-MS, for on-line trace gas analysis of breath. In: Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring, ed by A. Amann, D. Smith (World Scientific, Singapore, 2005) pp. 3–34Google Scholar