Applied Physics A

, Volume 93, Issue 1, pp 39–43 | Cite as

Nanoparticle injection to single animal cells using femtosecond laser-induced impulsive force

  • Atsushi Yamaguchi
  • Yoichiroh Hosokawa
  • Guillaume Louit
  • Tsuyoshi Asahi
  • Chisa Shukunami
  • Yuji Hiraki
  • Hiroshi Masuhara
Article

Abstract

An impulsive force, which was generated by focusing tightly a femtosecond laser into a cell culture medium, was applied to inject nanoparticles into local areas of a single mouse fibroblast NIH3T3 cell. When the impulsive force was induced near the cell, the nanoparticles adhering on the cell membrane were introduced, which was directly confirmed by confocal fluorescence microscopy.

PACS

42.62.-b 52.38.Mf 87.64.Tt 87.16.D- 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Atsushi Yamaguchi
    • 1
  • Yoichiroh Hosokawa
    • 1
    • 2
    • 3
  • Guillaume Louit
    • 1
  • Tsuyoshi Asahi
    • 1
  • Chisa Shukunami
    • 4
  • Yuji Hiraki
    • 3
    • 4
  • Hiroshi Masuhara
    • 1
    • 2
    • 3
  1. 1.Department of Applied Physics and Venture Business LaboratoryOsaka UniversityOsakaJapan
  2. 2.Hamano Life Science Research FoundationKobeJapan
  3. 3.CREST-JSTSaitamaJapan
  4. 4.Department of Cell Differentiation, Institute for Frontier Medical SciencesKyoto UniversityKyotoJapan

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