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Mammalian Genome

, Volume 10, Issue 11, pp 1085–1088 | Cite as

Structure of the murine E-selectin ligand 1 (ESL-1) gene and assignment to Chromosome 8

  • Frank  Willmroth
  • Arthur L.  Beaudet

Abstract.

A 150-kDa glycoprotein designated in the mouse as E-selectin ligand-1 (ESL-1; gene symbol Selel) was first isolated based on its ability to function as a ligand for E-selectin. The gene appears equivalent to that for membrane glycoprotein MG160 encoded in the human by the locus for Golgi apparatus protein 1 (GLG1). ESL-1 is also highly homologous to the chicken cysteine-rich fibroblast growth factor receptor (CFR). We describe the genomic structure and chromosomal localization of the Selel locus. The gene is encoded by 27 exons and extends over approximately 75 kb. It maps to murine Chromosome (Chr) 8 in a region homologous to human Chr 16q where the GLG1 locus maps, further indicating that Selel and GLG1 are mouse and human equivalents of the same gene.

Keywords

Growth Factor Growth Factor Receptor Fibroblast Growth Factor Fibroblast Growth Golgi Apparatus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1999

Authors and Affiliations

  • Frank  Willmroth
    • 1
  • Arthur L.  Beaudet
    • 1
  1. 1.Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAUS

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