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Mammalian Genome

, Volume 10, Issue 3, pp 299–302 | Cite as

Chromosomal localization of three human genes encoding bone morphogenetic protein receptors

  • Anna-Karin  Åström
  • Donald  Jin
  • Takeshi  Imamura
  • Eva  Röijer
  • Bradley  Rosenzweig
  • Kohei  Miyazono
  • Peter  ten Dijke
  • Göran  Stenman

Abstract.

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily that play a pivotal role in bone formation during embryogenesis and fracture repair. BMP signaling occurs via hetero-oligomeric serine/threonine kinase complexes of BMP type I (BMPR-IA or BMPR-IB) and type II receptors (BMPR-II). BMPR-IA and IB are closely related receptors, with sequence differences conserved between different species, suggesting that they serve distinct functions. Here we report the cDNA cloning of human BMPR1B and the chromosomal localization of all three BMPR genes. Using somatic cell hybrid and FISH analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q22-24, and 2q33-34, respectively. A processed BMPR1A pseudogene was mapped to 6q23.

Keywords

Bone Formation Somatic Cell cDNA Cloning Bone Morphogenetic Protein Chromosomal Localization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1999

Authors and Affiliations

  • Anna-Karin  Åström
    • 1
  • Donald  Jin
    • 4
  • Takeshi  Imamura
    • 3
  • Eva  Röijer
    • 1
  • Bradley  Rosenzweig
    • 5
  • Kohei  Miyazono
    • 3
  • Peter  ten Dijke
    • 2
  • Göran  Stenman
    • 1
  1. 1.Laboratory of Cancer Genetics, Department of Pathology, Göteborg University, Sahlgrenska University Hospital, SE-413 45 Göteborg, SwedenSE
  2. 2.Ludwig Institute for Cancer Research, Biomedical Center, Box 595, SE-751 24 Uppsala, SwedenSE
  3. 3.Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, Kami-ikebukuro, Toshima-ku, Tokyo 170, JapanJP
  4. 4.Creative Biomolecules Inc., 45 South Street, Hopkinton, Massachusetts 01748, USAUS
  5. 5.Amgen, 3200 Walnut Street, Boulder, Colorado 80301, USAUS

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