Mammalian Genome

, Volume 10, Issue 3, pp 294–298 | Cite as

PHF2, a novel PHD finger gene located on human Chromosome 9q22

  • Kerstin  Hasenpusch-Theil
  • Brian P.  Chadwick
  • Thomas  Theil
  • Stephanie K.  Heath
  • David G.  Wilkinson
  • Anna-Marie  Frischauf

Abstract.

We have isolated and characterized a novel PHD finger gene, PHF2, which maps to human Chromosome (Chr) 9q22 close to D9S196. Its mouse homolog was also characterized and mapped to the syntenic region on mouse Chr 13. The predicted human and mouse proteins are 98% identical and contain a PHD finger domain, eight possible nuclear localization signals, two potential PEST sequences, and a novel conserved hydrophobic domain. Northern analysis shows widespread expression of PHF2 in adult tissues, while in situ hybridization on mouse embryos reveals staining in the neural tube and dorsal root ganglia significantly above a ubiquitous low level expression signal. From its expression pattern and its chromosomal localization, PHF2 is a candidate gene for hereditary sensory neuropathy type I, HSN1.

Keywords

Dorsal Root Ganglion Neural Tube Human Chromosome Nuclear Localization Signal Sensory Neuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1999

Authors and Affiliations

  • Kerstin  Hasenpusch-Theil
    • 1
  • Brian P.  Chadwick
    • 1
  • Thomas  Theil
    • 2
  • Stephanie K.  Heath
    • 1
  • David G.  Wilkinson
    • 2
  • Anna-Marie  Frischauf
    • 1
  1. 1.Molecular Analysis of Mammalian Mutation, Imperial Cancer Research Fund, London WC2A 3PX, UKGB
  2. 2.Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UKGB

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