Mammalian Genome

, Volume 9, Issue 5, pp 349–354 | Cite as

Location of mouse and human genes corresponding to conserved canine olfactory receptor gene subfamilies

  • Ethan A. Carver
  • Laurie Issel-Tarver
  • Jasper Rine
  • Anne S. Olsen
  • Lisa Stubbs
Original Contributions


Olfactory receptors are G protein-coupled, seven-transmembrane-domain proteins that are responsible for binding odorants in the nasal epithelium. They are encoded by a large gene family, members of which are organized in several clusters scattered throughout the genomes of mammalian species. Here we describe the mapping of mouse sequences corresponding to four conserved olfactory receptor genes, each representing separate, recently identified canine gene subfamilies. Three of the four canine genes detected related gene clusters in regions of mouse Chromosomes (Chrs) 2, 9, and 10, near previously mapped mouse olfactory genes, while one detected a formerly unidentified gene cluster located on mouse Chr 6. In addition, we have localized two human gene clusters with homology to the canine gene, CfOLF4, within the established physical map of Chr 19p. Combined with recently published studies, these data link the four conserved olfactory gene subfamilies to homologous regions of the human, dog, and mouse genomes.


Rine Olfactory Receptor Mouse Chromosome Gene Subfamily Olfactory Receptor Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • Ethan A. Carver
    • 1
    • 2
  • Laurie Issel-Tarver
    • 3
  • Jasper Rine
    • 3
  • Anne S. Olsen
    • 4
  • Lisa Stubbs
    • 1
  1. 1.Life Sciences DivisionOak Ridge National LaboratoryOak RidgeUSA
  2. 2.Oak Ridge National LaboratoryUniversity of Tennessee-Oak Ridge School of Biomedical SciencesOak RidgeUSA
  3. 3.Division of Genetics, Department of Molecular and Cell BiologyUniversity of CaliforniaBerkeleyUSA
  4. 4.Lawrence Livermore National LaboratoryHuman Genome CenterLivermoreUSA

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