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Mammalian Genome

, Volume 9, Issue 5, pp 349–354 | Cite as

Location of mouse and human genes corresponding to conserved canine olfactory receptor gene subfamilies

  • Ethan A. Carver
  • Laurie Issel-Tarver
  • Jasper Rine
  • Anne S. Olsen
  • Lisa Stubbs
Original Contributions

Abstract

Olfactory receptors are G protein-coupled, seven-transmembrane-domain proteins that are responsible for binding odorants in the nasal epithelium. They are encoded by a large gene family, members of which are organized in several clusters scattered throughout the genomes of mammalian species. Here we describe the mapping of mouse sequences corresponding to four conserved olfactory receptor genes, each representing separate, recently identified canine gene subfamilies. Three of the four canine genes detected related gene clusters in regions of mouse Chromosomes (Chrs) 2, 9, and 10, near previously mapped mouse olfactory genes, while one detected a formerly unidentified gene cluster located on mouse Chr 6. In addition, we have localized two human gene clusters with homology to the canine gene, CfOLF4, within the established physical map of Chr 19p. Combined with recently published studies, these data link the four conserved olfactory gene subfamilies to homologous regions of the human, dog, and mouse genomes.

Keywords

Rine Olfactory Receptor Mouse Chromosome Gene Subfamily Olfactory Receptor Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ashworth LK, Batzer MA, Brandriff B, Branscomb E, deJong P, Garcia E, Garnes J, Gordon L, Lamerdin JE, Lennon G, Mohrenweiser H, Olsen A, Slezak T, Carrano AV (1995) A metric physical map of human chromosome 19. Nat Genet 11, 422–427PubMedCrossRefGoogle Scholar
  2. Bairoch A, Boeckmann B (1993) The SWISS-PROT protein sequence data bank, recent developments. Nucleic Acids Res 21, 3093–3096PubMedCrossRefGoogle Scholar
  3. Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H, North MA (1994) Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. Hum Mol Genet 3, 229–235PubMedCrossRefGoogle Scholar
  4. Brandriff BF, Gordon LA, Fertitta A, Olsen AS, Christensen M, Ashworth LK, Nelson DO, Carrano AV, Mohrenweiser HW (1994) Human chromosome 19p: a fluorescence in situ hybridization map with genomic distance estimates for 79 intervals spanning 20 Mb. Genomics 23, 582–591PubMedCrossRefGoogle Scholar
  5. Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65, 175–187PubMedCrossRefGoogle Scholar
  6. Chess A, Simon I, Cedar H, Axel R (1994). Allelic inactivation regulates olfactory receptor gene expression. Cell 78, 823–834PubMedCrossRefGoogle Scholar
  7. Copeland NE, Jenkins NA, Gilbert DJ, Eppig JT, Maltais LJ, Miller JC, Dietrich, WF, Weaver A, Lincoln SE, Steen RG, Stein LD, Nadeau JH, Lander ES (1993) A genetic linkage map of the mouse: current applications and future prospects. Science 262, 57–66PubMedCrossRefGoogle Scholar
  8. DeBry RW, Seidin MF (1996) Human/mouse homology relationships. Genomics 33, 337–51PubMedCrossRefGoogle Scholar
  9. Doyle J, Hoffman S, Ucla C, Reith W, Mach B, Stubbs L (1996) Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. Genomics 35, 227–230PubMedCrossRefGoogle Scholar
  10. Featherstone MS, Baron A, Gaunt SJ, Mattei MG, Duboule D (1988) Hox-5. 1 defines a homeobox-containing gene locus on mouse chromosome 2. Proc Natl Acad Sci USA 85, 4760–4764PubMedCrossRefGoogle Scholar
  11. Friezner-Degen SJ, Schaefer LA, Jamison CS, Grant SG, Fitzgibbon JJ, Pai JA, Chapman VM, Elliott RW (1990) Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2. DNA Cell Biol 9, 487–498CrossRefGoogle Scholar
  12. Glaser T, Gerhard D, Jones C, Albritton L, Lalley P, Housman D (1985) A fine structure deletion map of chromosome 11p. Cytogenet Cell Genet 40, 643Google Scholar
  13. Hillier L, Clark N, Dubuque T, Elliston K, Hawkins M, Holman M, Hultman M, Kucaba T, Le M, Lennon G, Marra M, Parsons J, Rifkin L, Rohlfing T, Tan F, Trevaskis E, Waterston R, Williamson A, Wohldmann P, Wilson R (1995) WashU-Merck EST Project. Unpublished.Google Scholar
  14. Horley KJ, Carpenito C, Baker B, Takei F (1989) Molecular cloning of murine intercellular adhesion molecule (ICAM-1). EMBO J 8, 2889–2896PubMedGoogle Scholar
  15. Issel-Tarver L, Rine J (1996) Organization and expression of canine olfactory receptor genes. Proc Natl Acad Sci USA 93, 10897–10902PubMedCrossRefGoogle Scholar
  16. Issel-Tarver L, Rine J (1997) The evolution of mammalian olfactory receptor genes. Genetics 145, 185–195PubMedGoogle Scholar
  17. Korneluk RG, Mahuran DJ, Neote K, Klavins MH, O’Dowd BF, Tropak M, Willard HF, Anderson MJ, Lowden JA, Gravel RA (1986) Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease. J Biol Chem 261, 8407–8413PubMedGoogle Scholar
  18. Manly KF (1993) A MacIntosh program for the storage and analysis of experimental genetic mapping data. Mamm Genome 4, 303–313PubMedCrossRefGoogle Scholar
  19. Marra M, Hillier L, Allen M, Bowles M, Dietrich N, Dubuque T, Geisel S, Kucaba T, Lacy M, Le M, Martin J, Morris M, Schellenberg K, Steptoe M, Tan F, Underwood K, Moore B, Theising B, Wylie T, Lennon G, Soares B, Wilson R, Waterston R (1996) The WashU-HHMI Mouse EST Project. Unpublished.Google Scholar
  20. MacDonald G, Chu ML, Cox DR (1991) Fine structure physical mapping of the region of mouse chromosome 10 homologous to human chromosome 21. Genomics 11, 317–323PubMedCrossRefGoogle Scholar
  21. Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, Pietryga DW, Scott WJ, Potter SS (1991) A functional c-myb gene is required for normal murine fetal hepatic hematopoisis. Cell 65, 677–689PubMedCrossRefGoogle Scholar
  22. Nef S, Allaman I, Fiumelli H, De Castro E, Nef P (1996) Olfaction in birds: differential embryonic expression of nine punative odorant receptor genes in the avian olfactory system. Mech Dev 55, 65–77PubMedCrossRefGoogle Scholar
  23. Nguyen VC, Ray D, Gross MS, de Tand MF, Frezal J, Moreau-Gachelin F (1990) Localization of the human oncogene SPI1 on chromosome 11, region p11. 22. Hum Genet 84, 542–546PubMedGoogle Scholar
  24. Olsen A, Teglund S, Nelson D, Gordon L, Copeland A, Georgescu A, Carrano A, Hammarstrom S (1994) Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700 kb cosmid contig spanning the region. Genomics 23, 659–668PubMedCrossRefGoogle Scholar
  25. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, Grootegoed A, Vassart G (1992) Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature 355, 453–455PubMedCrossRefGoogle Scholar
  26. Paul R, Schuetze S, Kozak SL, Kozak CA, Kabat D (1991) The Sfpi-1 proviral integration site of Friend erythroleukemia encodes the etsrelated transcription factor Pu. 1. J Virol 65, 464–467PubMedGoogle Scholar
  27. Pohlmann R, Krentler C, Schmidt B, Schroder W, Lorkowski G, Culley J, Mersmann, G, Geier C, Waheed A, Gottschalk S, Grzeschik K-H, Hasilik A, von Figura K (1988) Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment. EMBO J 7, 2343–2350PubMedGoogle Scholar
  28. Quan F, Korneluk RG, Tropak MB, Gravel RA (1986) Isolation and characterization of the human catalase gene. Nucleic Acids Res 14, 5321–5335PubMedCrossRefGoogle Scholar
  29. Ressler KJ, Sullivan SL, Buck LB (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell 73, 597–609PubMedCrossRefGoogle Scholar
  30. Silver J (1985) Confidence limits for estimates of gene linkage analysis of recombinant inbred strains. J Hered 76, 436–440PubMedGoogle Scholar
  31. Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, Selleri L, McElligott DL, Evans GA (1993) A sequence-tagged site map of human chromosome 11. Genomics 17, 699–725PubMedCrossRefGoogle Scholar
  32. Stubbs L, Huxley C, Hogan B, Evans T, Fried M, Duboule D, Lehrach H (1990) The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2. Genomics 6, 645–650PubMedCrossRefGoogle Scholar
  33. Stubbs L, Carver E, Ashworth L, Lopez-Molina L (1996) Location of the DBP transcription factor gene in man and mouse. Mamm Genome 7, 65–67PubMedCrossRefGoogle Scholar
  34. Sullivan SL, Adamson MC, Ressler KJ, Kozak CA, Buck LB (1996) The chromosomal distribution of mouse odorant receptor genes. Proc Natl Acad Sci USA 93, 884–888PubMedCrossRefGoogle Scholar
  35. Taylor BA, Burmeister M, Bryda EC (1996) Mouse Chromosome 10. Mamm Genome 6(Suppl), S190-S200.PubMedGoogle Scholar
  36. Wilson RW, O’Brein WE, Beaudet AL (1989) Nucleotide sequence of the cDNA from the mouse leukocyte adhesion protein CD18. Nucleic Acids Res 17, 5397PubMedCrossRefGoogle Scholar
  37. Yamamoto T, Davis CG, Brown MS, Schneider WJ, Casey ML, Goldstein JL, Russell DW (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell 39, 27–38PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • Ethan A. Carver
    • 1
    • 2
  • Laurie Issel-Tarver
    • 3
  • Jasper Rine
    • 3
  • Anne S. Olsen
    • 4
  • Lisa Stubbs
    • 1
  1. 1.Life Sciences DivisionOak Ridge National LaboratoryOak RidgeUSA
  2. 2.Oak Ridge National LaboratoryUniversity of Tennessee-Oak Ridge School of Biomedical SciencesOak RidgeUSA
  3. 3.Division of Genetics, Department of Molecular and Cell BiologyUniversity of CaliforniaBerkeleyUSA
  4. 4.Lawrence Livermore National LaboratoryHuman Genome CenterLivermoreUSA

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