Mammalian Genome

, 8:927 | Cite as

Mapping of new recessive cataract gene (itIr2) in the mouse

  • Chang-Woo Song
  • Masaaki Okumoto
  • Nobuko Mori
  • Jin-Suk Kim
  • San-Seop Han
  • Kozaburo Esaki
Original Contribution

Abstract

A new strain of mice with cataracts was developed in BALB/cHeA and STS/A recombinant inbred strain, CXS4 (D). In this study the mapping of spontaneous autosomal recessive cataract mutation is described. This mutation was characterized by ruptures of the lens nucleus, vitreous chamber through the posterior capsule, and the vacuolization of the lens. For the linkage analysis, we produced two kinds of backcross progenies, (BALB/cHeA x D)F1 and (STS/A x D)F1 females crossed to D male mice. The gene (Ir2, lens rupture2) was mapped to the central part of Chromosome(Chr) 14, 0.7 ± 0.7cM from the micosatellite rnarker D14Mit28.

Keywords

Cataract Recombinant Inbred Backcross Progeny Recombinant Inbred Strain Lens Cataract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Chang-Woo Song
    • 1
    • 4
  • Masaaki Okumoto
    • 2
  • Nobuko Mori
    • 2
  • Jin-Suk Kim
    • 3
  • San-Seop Han
    • 4
  • Kozaburo Esaki
    • 1
  1. 1.Laboratory of Experimental AnimalsCollege of AgricultureOsakaJapan
  2. 2.Division of Bionics, Department of Applied Bioscience, Research Institute of Advanced Science and TechnologyOsaka Prefecture UniversityOsakaJapan
  3. 3.Department of Veterinary Medicine and Animal Resources Research CenterKon Kuk UniversitySeoulRepublic of Korea
  4. 4.Toxicological Research CenterKorea Research Institute of Chemical TechnologyYusung-gu, Taejeon-siRepublic of Korea

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