Mammalian Genome

, 8:801 | Cite as

Pas1 is a common lung cancer susceptibility locus in three mouse strains

  • Giacomo Manenti
  • Manuela Gariboldi
  • Antonio Fiorino
  • Antonio I. Zedda
  • Marco A. Pierotti
  • Tommaso A. Dragani
Original Contribution

Abstract

Inherited predisposition to lung cancer is a phenotypic trait shared by different mouse inbred strains that show either a high or an intermediate predisposition. Other strains are instead genetically resistant. The Pasl locus is the major determinant of lung cancer predisposition in the A/J strain (Gariboldi et al. 1993). To define the determinants of susceptibility to lung tumorigenesis in the highly susceptible SWR/J and in the intermediately susceptible BALB/c mice, we analyzed (BALB/c x SWR/J)F2 and (BALB/c x C3H/He)F2 crosses by genetic linkage experiments. The present results provide unequivocal evidence that the same Pas1/+ allele that leads to lung cancer predisposition is shared by A/J, SWR/J, and BALB/c strains. The intermediate susceptibility of the BALB/c strain would result by interaction of Pas1 locus with lung cancer resistance loci.

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Giacomo Manenti
    • 1
  • Manuela Gariboldi
    • 1
  • Antonio Fiorino
    • 1
  • Antonio I. Zedda
    • 1
  • Marco A. Pierotti
    • 1
  • Tommaso A. Dragani
    • 1
  1. 1.Division of Experimental Oncology AIstituto Nazionale TumoriMilanItaly

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