Mammalian Genome

, Volume 8, Issue 11, pp 799–800

Mutation watch: Mouse brachyury (T), the T-box gene family, and human disease

  • Miriam H. Meisler
Review

References

  1. Agulnik SI, Bollag RJ, Silver LM (1995) Conservation of the T-box gene from Mus musculus to Caenorhabditis elegans. Genomics 25, 214–219PubMedCrossRefGoogle Scholar
  2. Bamshad M, Lin RC, Law DJ, Watkins WS, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC, Bruneau BG, Scidman JG, Scidman CE, Jorde LB (1997) Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nature Genet, in pressGoogle Scholar
  3. Basson CT, Bachinsky DR, Lin RC, Levi T, Elkins JA, Soults J, Grayzel D, Kroumpouzou E, Traill TA, Leblanc-Straceski J, Renault B, Kucherlapati R, Seidman JG, Scidman CE (1997) Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome. Nature Genet 15, 30–35PubMedCrossRefGoogle Scholar
  4. Bollag RJ, Siegfried Z, Cebra-Thomas JA, Garvey N, Davison EM, Silver LM (1994) An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nature Genet 7, 383–389PubMedCrossRefGoogle Scholar
  5. Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L, Rubenstein JL (1995) T-brain-1: a homolog of brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron 15, 63–78PubMedCrossRefGoogle Scholar
  6. Edwards YH, Putt W, Lekoape KM, Stott D, Fox M, Hopkinson DA, Sowden J (1996) The human homolog T of the mouse T(brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27. Genome Res 6, 226–233PubMedCrossRefGoogle Scholar
  7. Herrmann BG, Labeit S, Poustka A, King TR, Lehrach H (1990) Cloning of the T gene required in mesoderm formation in the mouse. Nature 343, 617–622PubMedCrossRefGoogle Scholar
  8. Kispert A, Koschorz B, Herrmann BG (1995) The T protein encoded by brachyury is a tissue-specific transcription factor. EMBO J 14, 4763–4772PubMedGoogle Scholar
  9. Li QY, Newbury-Ecob RA, Terrett JA, Wilson DI, Curtis ARJ, Yi CH, Gebuhr T, Bullen PJ, Robson SC, Strachan T, Bonnet D, Lyonnet S, Young ID, Raeburn JA, Buckler AJ, Law DJ, Brook JD (1997) Holt-Oram Syndrome is caused by mutations in TBX5, a member of Brachyury (T) family. Nature Genet 15, 21–29PubMedCrossRefGoogle Scholar
  10. Pflugfelder GO, Roth H, Poeck B (1992) A homology domain shared between Drosophila optomotor-blind and mouse brachyury is involved in DNA binding. Biochem Biophys Res Commun 186, 918–925PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Miriam H. Meisler
    • 1
  1. 1.Department of Human GeneticsUniversity of MichiganAnn ArborUSA

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