Mammalian Genome

, Volume 8, Issue 5, pp 324–327 | Cite as

The LEXF: A new set of rat recombinant inbred strains between LE/Stm and F344

  • Hayase Shisa
  • Lingmin Lu
  • Hideki Katoh
  • Atsuko Kawarai
  • Jun-ichi Tanuma
  • Yoshibumi Matsushima
  • Hiroshi Hiai
Original Contribution
Received:
Accepted:

Abstract

A new set of rat RI strains consisting of 11 independent strains and 13 of their substrains was established by inbreeding F2 rats between F344/DuCrj and LE/Stm. The strain distribution pattern was examined for 66 microsatellite loci, 8 biochemical genetic markers, 2 histocompatibility loci, and 2 coat color genes. A rat salivary protein gene Spe1 was newly mapped on Chr 1.

Keywords

Coat Color Recombinant Inbred Salivary Protein Strain Distribution Pattern Mouse Recombinant Inbred 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams M, Baverstock PA, Watts CHS, Gutman GA (1984) Enzyme markers in inbred rat strains: genetics of new markers and strain profiles. Biochem Genet 22, 611–629PubMedCrossRefGoogle Scholar
  2. Arenas O, Wagener DK, Kunz HW, Gill TJ III (1981) Comparison of the haplotypes of the major histocompatibility complex in the rat. V. A serological, genetic and numerical study of the RT1. A region antigens. J Immunogenet. 8, 307–314PubMedCrossRefGoogle Scholar
  3. Bailey DW (1981) Recombinant inbred strains and bilinear congenic strains. In The Mouse in Biomedical Research: History, Genetics and Wild Mice. HL Foster, JD Small, JG Fox, eds. (New York:), Academic Press, pp 223–239Google Scholar
  4. Bender K, Cleve H, Günther E (1981) A previously described serum protein polymorphism in the rat identified as Gc (Vitamin D-binding protein). Anim Blood Groups Biochem Genet 12, 31–36PubMedGoogle Scholar
  5. Dietrich W, Katz H, Lincoln SE, Shin HS, Friedman J, Dracopoli N, Lander ES (1992) A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131, 423–447PubMedGoogle Scholar
  6. Hedrich HJ (1990) Recombinant inbred strains. In Genetic Monitoring of Inbred Strains of Rats, HJ Hedrich, ed (Stuttgart-New York: Gustav Fischer Verlag), pp 487–494Google Scholar
  7. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lerenmark A, Levan G, Mao Y-P, Pettersen A, Pravenec M, Simon JS, Szpirer C, Szpirer J, Trolliet MR, Winer ES, Lander ES (1995) A genetic linkage map of the laboratory rat, Rattus norvegicns. Nature Genet 9, 63–69PubMedCrossRefGoogle Scholar
  8. Kondo Y, Hamada S, Serikawa T, Yamada J (1989) Second genetic polymorphism of tear proteins in the rat (Rtp-2). Exp Anim 38, 327–331Google Scholar
  9. Kunz HW, Misra DN, Gill TJ (1985) Production of monoclonal antibodies against RT2 antigens of the rat and definition of a new locus RT9, linked to RT2. J Immunogenet 12, 75–78PubMedCrossRefGoogle Scholar
  10. Matsushima Y, Ikemoto S (1983) Genetic analysis of mouse tear protein system-1 (Mtp-1). Jpn J Zootech Sci 54, 269–274Google Scholar
  11. Nishimura M, Hirayama N, Serikawa T, Kanehira K, Matsushima Y, Katoh H, Wakana S, Kojima A, Hiai H (1995) The SMXA: a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile. Mamm Genome 6, 850–857PubMedCrossRefGoogle Scholar
  12. Pravenec M, Simonet L, Kren V, St. Lezin E, Levan G, Szpirer J, Szpirer C, Kurtz T (1992) Assignment of rat linkage V to chromosome 19 by single strand conformation polymorphism analysis of somatic cell hybrids. Genomics 12, 350–356PubMedCrossRefGoogle Scholar
  13. Pravenec M, Gauguier D, Schott JJ, Buard J, Kren V, Bila V, Szpirer C, Szpirer J, Wang JM, Huang H, St. Lezin E, Spence MA, Flodman P, Printz M, Lathrop GM, Vergnaud G, Kurtz TW (1996) A genetic linkage map of the rat derived from recombinant inbred strains. Mamm Genome 7, 117–127PubMedCrossRefGoogle Scholar
  14. Serikawa T, Kuramoto T, Hilbert P, Mori M, Yamada J, Dubay CJ, Lind-painter K, Ganten D, Guénet J-L, Lathrop M, Beckmann JJ (1992) Rat gene mapping using PCR-analyzed microsatellites. Genetics 131, 703–722Google Scholar
  15. Shisa H, Hiai H (1985) Genetically determined susceptibility of Fisher 344 rats to propylnitrosourea-induced thymic lymphomas. Cancer Res 45, 1483–1487PubMedGoogle Scholar
  16. Silver LM (1995) Mouse Genetics. (Oxford, UK: Oxford University Press), pp 32–61Google Scholar
  17. Stahl F, Szpirer J, Klinga-Levan K, Szpirer C, Levan G (1996) The rat gene map 1996: fall revision. Rat Genome 2, 154–196Google Scholar
  18. Taylor BA (1978) Recombinant inbred strains. Use in gene mapping. In Origins of Inbred Mice, HCI Morse, ed. (New York: Academic Press), pp 423–438Google Scholar
  19. Taylor BA (1989) Recombination inbred strains. In Genetic Variants and Strains of the Laboratory Mouse, M.F. Lyon, A.G. Searle, eds (Oxford, UK: Oxford University Press), pp 773–796Google Scholar
  20. Yamada Y, Matsushiro H, Shimada MO, Toyokuni S, Okamoto K, Fuku-moto M, Hiai H (1994) Genetic susceptibility to pre-B lymphoma in SL/Kh strain mice. Cancer Res 54, 403–407PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Hayase Shisa
    • 1
  • Lingmin Lu
    • 2
  • Hideki Katoh
    • 3
  • Atsuko Kawarai
    • 1
  • Jun-ichi Tanuma
    • 1
  • Yoshibumi Matsushima
    • 4
  • Hiroshi Hiai
    • 2
  1. 1.Department of PathologySaitama Cancer Center Research InstituteIna, SaitamaJapan
  2. 2.Department of Pathology and Biology of DiseasesKyoto University Graduate School of MedicineYoshida-Konoe-cho, Sakyo-ku, KyotoJapan
  3. 3.Central Institute for Experimental AnimalsKawasakiJapan
  4. 4.Laboratory of Experimental Animal ScienceSaitama Cancer Center Research InstituteIna, SaitamaJapan

Personalised recommendations