Mammalian Genome

, Volume 7, Issue 7, pp 501–504

Genetic mapping of the human and mouse phospholipase C genes

  • M. S. Lyu
  • D. J. Park
  • S. G. Rhee
  • C. A. Kozak
Original Contribution

DOI: 10.1007/s003359900151

Cite this article as:
Lyu, M.S., Park, D.J., Rhee, S.G. et al. Mammalian Genome (1996) 7: 501. doi:10.1007/s003359900151

Abstract

To determine chromosome positions for 10 mouse phospholipase C (PLC) genes, we typed the progeny of two sets of genetic crosses for inheritance of restriction enzyme polymorphisms of each PLC. Four mouse chromosomes, Chr 1, 11, 12, and 19, contained single PLC genes. Four PLC loci, Plcb1, Plcb2, Plcb4, and Plcg1, mapped to three sites on distal mouse Chr 2. Two PLC genes, Plcd1 and Plcg2, mapped to distinct sites on Chr 8. We mapped the human homologs of eight of these genes to six chromosomes by analysis of human x rodent somatic cell hybrids. The map locations of seven of these genes were consistent with previously defined regions of conserved synteny; Plcd1 defines a new region of homology between human Chr 3 and mouse Chr 8.

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • M. S. Lyu
    • 1
  • D. J. Park
    • 2
    • 3
  • S. G. Rhee
    • 2
  • C. A. Kozak
    • 1
  1. 1.Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.Laboratory of Signal Transduction, National Heart, Lung, and Blood InstituteNational Institutes of HealthBethesdaUSA
  3. 3.Department of Internal MedicineSeoul National University Medical SchoolYunkun-dong, Chongro-ku, SeoulKorea

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