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Mammalian Genome

, 7:285 | Cite as

A comparative map of the porcine and human genomes demonstrates ZOO-FISH and gene mapping-based chromosomal homologies

  • L. Frönicke
  • B. P. Chowdhary
  • H. Scherthan
  • I. Gustavsson
Original Contributions

Abstract

ZOO-FISH with chromosome-specific DNA libraries (CSLs) from individual flow-sorted human chromosomes was applied on porcine metaphase chromosomes to establish segment homology between the pig and human karyotypes. Forty-seven porcine chromosomal segments corresponding to all human chromosomes except the Y were delineated, resulting in a nearly complete coverage of the porcine karyotype. The syntenic segments detected were further confirmed by the gene mapping information available in the two species. A map demarcating physical boundaries of human homologies on individual pig chromosomes is complemented with a detail survey of the physical and genetic linkage mapping data in the two species. The resultant map, thus, provides a comprehensive and updated comparative status of the human and porcine genomes.

Keywords

Human Chromosome Homologous Segment Porcine Genome Porcine Chromosome Comparative Chromosome Painting 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • L. Frönicke
    • 1
  • B. P. Chowdhary
    • 2
  • H. Scherthan
    • 1
  • I. Gustavsson
    • 2
  1. 1.Division of Human Biology and Human GeneticsUniversity of KaiserslauternKaiserslauternGermany
  2. 2.Department of Animal Breeding and GeneticsSwedish University of Agricultural SciencesUppsalaSweden

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