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Manipulating the tumor microenvironment by adoptive cell transfer of CAR T-cells

  • Kavitha Gowrishankar
  • Lucy Birtwistle
  • Kenneth Micklethwaite
Article

Abstract

T-cells expressing synthetic chimeric antigen receptors (CARs) have revolutionized immuno-oncology and highlighted the use of adoptive cell transfer, for the treatment of cancer. The phenomenal clinical success obtained in the treatment of hematological malignancies with CAR T-cells has not been reproduced in the treatment of solid tumors, mainly due to the suppressive and hostile tumor microenvironment (TME). This review will address the immunosuppressive features of the TME, which include the stroma, cytokine and chemokine milieu, suppressive regulatory cells and hypoxic conditions, which can all pose formidable barriers for the effective anti-tumor function of CAR T-cells. Some of the novel next generation CARs that have been developed and tested against the TME, will be discussed, to highlight the status of current research in CAR T-cell therapy for solid tumors.

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Kavitha Gowrishankar
    • 1
  • Lucy Birtwistle
    • 1
  • Kenneth Micklethwaite
    • 1
    • 2
  1. 1.Westmead Institute for Medical ResearchThe University of SydneySydneyAustralia
  2. 2.Sydney Cellular Therapies Laboratory; Blood and Bone Marrow Transplant Unit; Department of Haematology; Sydney Medical SchoolWestmead HospitalSydneyAustralia

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