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Mammalian Genome

, Volume 28, Issue 1–2, pp 13–19 | Cite as

Quantitative trait loci that control body weight in DDD/Sgn and C57BL/6J inbred mice

  • Jun-ichi SutoEmail author
  • Misaki Kojima
Article

Abstract

Inbred DDD/Sgn mice are heavier than inbred C57BL/6J mice. In the present study, we performed quantitative trait loci (QTL) mapping for body weight using R/qtl in reciprocal F2 male populations between the two strains. We identified four significant QTL on Chrs 1, 2, 5, and 17 (proximal region). The DDD/Sgn allele was associated with increased body weight at QTL on Chrs 1 and 5, and the DDD/Sgn allele was associated with decreased body weight at QTL on Chrs 2 and 17. A multiple regression analysis indicated that the detected QTL explain 30.94 % of the body weight variation. Because DDD/Sgn male mice have extremely high levels of circulating testosterone relative to other inbred mouse strains, we performed QTL mapping for plasma testosterone level to examine the effect of testosterone levels on body weight. We identified one suggestive QTL on Chr 5, which overlapped with body weight QTL. The DDD/Sgn allele was associated with increased testosterone level. Thus, we confirmed that there was a genetic basis for the changes in body weight and testosterone levels in male mice. These findings provide insights into the genetic mechanism by which body weight is controlled in male mice.

Keywords

Quantitative Trait Locus Testosterone Level Quantitative Trait Locus Mapping Quantitative Trait Locus Effect Significant Quantitative Trait Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This study was supported in part by the NIAS Strategic Research Fund.

Supplementary material

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Institute of Agrobiological SciencesNational Agriculture and Food Research Organization (NARO)TsukubaJapan
  2. 2.Institute of Livestock and Grassland ScienceNational Agriculture and Food Research Organization (NARO)TsukubaJapan

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