Mammalian Genome

, Volume 23, Issue 9–10, pp 680–692 | Cite as

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

  • Anatole Ghazalpour
  • Christoph D. Rau
  • Charles R. Farber
  • Brian J. Bennett
  • Luz D. Orozco
  • Atila van Nas
  • Calvin Pan
  • Hooman Allayee
  • Simon W. Beaven
  • Mete Civelek
  • Richard C. Davis
  • Thomas A. Drake
  • Rick A. Friedman
  • Nick Furlotte
  • Simon T. Hui
  • J. David Jentsch
  • Emrah Kostem
  • Hyun Min Kang
  • Eun Yong Kang
  • Jong Wha Joo
  • Vyacheslav A. Korshunov
  • Rick E. Laughlin
  • Lisa J. Martin
  • Jeffrey D. Ohmen
  • Brian W. Parks
  • Matteo Pellegrini
  • Karen Reue
  • Desmond J. Smith
  • Sotirios Tetradis
  • Jessica Wang
  • Yibin Wang
  • James N. Weiss
  • Todd Kirchgessner
  • Peter S. Gargalovic
  • Eleazar Eskin
  • Aldons J. Lusis
  • Renée C. LeBoeuf
Article

Abstract

We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5 % of total trait variance). Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Anatole Ghazalpour
    • 1
  • Christoph D. Rau
    • 2
  • Charles R. Farber
    • 3
  • Brian J. Bennett
    • 4
  • Luz D. Orozco
    • 5
  • Atila van Nas
    • 5
  • Calvin Pan
    • 5
  • Hooman Allayee
    • 6
  • Simon W. Beaven
    • 7
  • Mete Civelek
    • 1
  • Richard C. Davis
    • 1
  • Thomas A. Drake
    • 8
  • Rick A. Friedman
    • 9
  • Nick Furlotte
    • 10
  • Simon T. Hui
    • 1
  • J. David Jentsch
    • 11
  • Emrah Kostem
    • 10
  • Hyun Min Kang
    • 12
  • Eun Yong Kang
    • 10
  • Jong Wha Joo
    • 5
    • 13
  • Vyacheslav A. Korshunov
    • 14
  • Rick E. Laughlin
    • 15
  • Lisa J. Martin
    • 5
  • Jeffrey D. Ohmen
    • 16
  • Brian W. Parks
    • 1
  • Matteo Pellegrini
    • 17
  • Karen Reue
    • 5
  • Desmond J. Smith
    • 18
  • Sotirios Tetradis
    • 19
    • 20
  • Jessica Wang
    • 5
    • 21
  • Yibin Wang
    • 22
  • James N. Weiss
    • 2
  • Todd Kirchgessner
    • 23
  • Peter S. Gargalovic
    • 23
  • Eleazar Eskin
    • 5
    • 10
  • Aldons J. Lusis
    • 1
    • 2
    • 5
    • 20
  • Renée C. LeBoeuf
    • 24
  1. 1.Department of Medicine, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of Microbiology, Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesUSA
  3. 3.Departments of Medicine and Biochemistry and Molecular Genetics, and Center for Public Health GenomicsUniversity of VirginiaCharlottesvilleUSA
  4. 4.Department of Genetics, and Nutrition Research InstituteUniversity of North CarolinaChapel HillUSA
  5. 5.Department of Human Genetics, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  6. 6.Department of Preventive Medicine, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  7. 7.Division of Digestive Diseases, Department of Medicine, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  8. 8.Department of Pathology and Laboratory Medicine, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  9. 9.Department of Otology/Skull Base SurgeryHouse Research InstituteLos AngelesUSA
  10. 10.Department of Computer SciencesUniversity of CaliforniaLos AngelesUSA
  11. 11.Department of Psychology & Behavioral Neuroscience and Psychiatry & Biobehavioral Sciences, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  12. 12.Department of Biostatistics, School of Public HealthUniversity of MichiganAnn ArborUSA
  13. 13.Bioinformatics Program, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  14. 14.Department of Medicine, Aab Cardiovascular Research InstituteUniversity of Rochester School of Medicine and DentistryRochesterUSA
  15. 15.Semel Institute for Neuroscience and Human BehaviorUniversity of CaliforniaLos AngelesUSA
  16. 16.Department of Cell Biology and GeneticsHouse Research InstituteLos AngelesUSA
  17. 17.Department of Molecular, Cell and Developmental BiologyUniversity of CaliforniaLos AngelesUSA
  18. 18.Department of Molecular and Medical Pharmacology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  19. 19.Molecular Biology Institute, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  20. 20.Division of Diagnostic and Surgical Science, School of DentistryUniversity of CaliforniaLos AngelesUSA
  21. 21.Department of Medicine/Cardiology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  22. 22.Division of Molecular Medicine, Department of Anesthesiology, Physiology and Medicine, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  23. 23.Department of Cardiovascular Drug DiscoveryBristol-Myers Squibb CoPenningtonUSA
  24. 24.Division of Metabolism, Endocrinology and Nutrition, Department of MedicineUniversity of WashingtonSeattleUSA

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