Genetics of canine olfaction and receptor diversity
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Olfaction is a particularly important sense in the dog. Humans selected for this capacity during the domestication process, and selection has continued to be employed to enhance this ability. In this review we first describe the different olfactory systems that exist and the different odorant receptors that are expressed in those systems. We then focus on the dog olfactory receptors by describing the olfactory receptor gene repertoire and its polymorphisms. Finally, we discuss the different uses of dog olfaction and the questions that still need to be studied.
KeywordsOlfactory Receptor Olfactory Epithelium Vomeronasal Organ Odorant Molecule Copy Number Variation Region
We deeply thank Dr. Jean-Paul Boidot for providing the schematic drawing of the dog head and Dr. Tyrone C. Spady for careful reading and editing of the manuscript.
- Brand-Arpon V, Rouquier S, Massa H, de Jong PJ, Ferraz C, Ioannou PA, Demaille JG, Trask BJ, Giorgi D (1999) A genomic region encompassing a cluster of olfactory receptor genes and a myosin light chain kinase (MYLK) gene is duplicated on human chromosome regions 3q13–q21 and 3p13. Genomics 56:98–110PubMedCrossRefGoogle Scholar
- Hashiguchi Y, Nishida M (2007) Evolution of trace amine associated receptor (TAAR) gene family in vertebrates: lineage-specific expansions and degradations of a second class of vertebrate chemosensory receptors expressed in the olfactory epithelium. Mol Biol Evol 24:2099–2107PubMedCrossRefGoogle Scholar
- Quignon P, Tacher S, Rimbault M, Galibert F (2006) The dog olfactory and vomeronasal receptor repertoires. In: Ostrander EA, Giger U, Lindblad-Toh K (eds) The dog and its genome. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 221–231Google Scholar
- Tortora GJ, Grabowski SR (2003) Principles of anatomy and physiology, 10th edn. Wiley, New YorkGoogle Scholar