Mammalian Genome

, Volume 23, Issue 1–2, pp 195–202 | Cite as

Empowering international canine inherited disorder management

Article

Abstract

The mapping of the canine genome and the study of canine breed genomic architecture has revolutionized the discovery of genetic tests for inherited disorders in dogs. As the genetics underlying complex disorders are revealed, canine breeders and their registering organisations will be required to understand genetics in a much more sophisticated way. To facilitate the management of genetic disorders in the era of new complex information, we consider how best to apply the results of new research and analytical techniques to benefit the wider canine breeding community with the aims of improving canine health and maintaining benevolent genetic diversity. If this is not done, there is a serious risk that expensive and valuable genetic research will remain unused or be misused to the detriment of breeds. In this review, we make a case for the formation of an international organisation that will exist as a central repository for breed-based genetic analysis and information sharing. This organisation (“Inter-Dog”) could be modelled on a similar organisation that is monitoring genetic improvement of dairy cattle. The formation of such an organisation will require the collaboration of international kennel management organisations, researchers, and agencies offering genetic testing services.

References

  1. Altshuler DL, Durbin RM, Abecasis GR, Bentley DR, Chakravarti A, Clark AG, Collins FS, De la Vega FM, Donnelly P, Egholm M, Flicek P, Gabriel SB, Gibbs RA, Knoppers BM, Lander ES, Lehrach H, Mardis ER, McVean GA, Nickerson D, Peltonen L, Schafer AJ, Sherry ST, Wang J, Wilson RK, Deiros D, Metzker M, Muzny D, Reid J, Wheeler D, Li JX, Jian M, Li G, Li RQ, Liang HQ, Tian G, Wang B, Wang W, Yang HM, Zhang XQ, Zheng HS, Ambrogio L, Bloom T, Cibulskis K, Fennell TJ, Jaffe DB, Shefler E, Sougnez CL, Gormley N, Humphray S, Kingsbury Z, Koko-Gonzales P, Stone J, McKernan KJ, Costa GL, Ichikawa JK, Lee CC, Sudbrak R, Borodina TA, Dahl A, Davydov AN, Marquardt P, Mertes F, Nietfeld W, Rosenstiel P, Schreiber S, Soldatov AV, Timmermann B, Tolzmann M, Affourtit J, Ashworth D, Attiya S, Bachorski M, Buglione E, Burke A, Caprio A, Celone C, Clark S, Conners D, Desany B, Gu L, Guccione L, Kao K, Kebbel A, Knowlton J, Labrecque M, McDade L, Mealmaker C, Minderman M, Nawrocki A, Niazi F, Pareja K, Ramenani R, Riches D, Song W, Turcotte C, Wang S, Dooling D, Fulton L, Fulton R, Weinstock G, Burton J, Carter DM, Churcher C, Coffey A, Cox A, Palotie A, Quail M, Skelly T, Stalker J, Swerdlow HP, Turner D, De Witte A, Giles S, Bainbridge M, Challis D, Sabo A, Yu F, Yu J, Fang XD, Guo XS, Li YR, Luo RB, Tai S, Wu HL, Zheng HC, Zheng XL, Zhou Y, Marth GT, Garrison EP, Huang W, Indap A, Kural D, Lee WP, Leong WF, Huang WC, Quinlan AR, Stewart C, Stromberg MP, Ward AN, Wu JT, Lee C, Mills RE, Shi XH, Daly MJ, DePristo MA, Ball AD, Banks E, Browning BL, Garimella KV, Grossman SR, Handsaker RE, Hanna M, Hartl C, Kernytsky AM, Korn JM, Li H, Maguire JR, McCarroll SA, McKenna A, Nemesh JC, Philippakis AA, Poplin RE, Price A, Rivas MA, Sabeti PC, Schaffner SF, Shlyakhter IA, Cooper DN, Ball EV, Mort M, Phillips AD, Stenson PD, Sebat J, Makarov V, Ye K, Yoon SC, Bustamante CD, Boyko A, Degenhardt J, Gravel S, Gutenkunst RN, Kaganovich M, Keinan A, Lacroute P, Ma X, Reynolds A, Clarke L, Cunningham F, Herrero J, Keenen S, Kulesha E, Leinonen R, McLaren W, Radhakrishnan R, Smith RE, Zalunin V, Zheng-Bradley XQ, Korbel JO, Stutz AM, Bauer M, Cheetham RK, Cox T, Eberle M, James T, Kahn S, Murray L, Fu YT, Hyland FCL, Manning JM, McLaughlin SF, Peckham HE, Sakarya O, Sun YA, Tsung EF, Batzer MA, Konkel MK, Walker JA, Albrecht MW, Amstislavskiy VS, Herwig R, Parkhomchuk DV, Agarwala R, Khouri H, Morgulis AO, Paschall JE, Phan LD, Rotmistrovsky KE, Sanders RD, Shumway MF, Xiao CL, Auton A, Iqbal Z, Lunter G, Marchini JL, Moutsianas L, Myers S, Tumian A, Knight J, Winer R, Craig DW, Beckstrom-Sternberg SM, Christoforides A, Kurdoglu AA, Pearson J, Sinari SA, Tembe WD, Haussler D, Hinrichs AS, Katzman SJ, Kern A, Kuhn RM, Przeworski M, Hernandez RD, Howie B, Kelley JL, Melton SC, Li Y, Anderson P, Blackwell T, Chen W, Cookson WO, Ding J, Kang HM, Lathrop M, Liang LM, Moffatt MF, Scheet P, Sidore C, Snyder M, Zhan XW, Zollner S, Awadalla P, Casals F, Idaghdour Y, Keebler J, Stone EA, Zilversmit M, Jorde L, Xing JC, Eichler EE, Aksay G, Alkan C, Hajirasouliha I, Hormozdiari F, Kidd JM, Sahinalp SC, Sudmant PH, Chen K, Chinwalla A, Ding L, Koboldt DC, McLellan MD, Wallis JW, Wendl MC, Zhang QY, Albers CA, Ayub Q, Balasubramaniam S, Barrett JC, Chen YA, Conrad DF, Danecek P, Dermitzakis ET, Hu M, Huang N, Hurles ME, Jin HJ, Jostins L, Keane TM, Le SQ, Lindsay S, Long QA, MacArthur DG, Montgomery SB, Parts L, Tyler-Smith C, Walter K, Zhang YJ, Gerstein MB, Abyzov A, Balasubramanian S, Bjornson R, Du JA, Grubert F, Habegger L, Haraksingh R, Jee J, Khurana E, Lam HYK, Leng J, Mu XJ, Urban AE, Zhang ZD, Coafra C, Dinh H, Kovar C, Lee S, Nazareth L, Yu FL, Wilkinson J, Khouri HM, Scott C, Gharani N, Kaye JS, Kent A, Li T, McGuire AL, Ossorio PN, Rotimi CN, Su YY, Toji LH, Brooks LD, Felsenfeld AL, McEwen JE, Abdallah A, Christopher R, Clemm NC, Duncanson A, Green ED, Guyer MS, Peterson JL, 1000 Genomes project consortium (2010) A map of human genome variation from population-scale sequencing. Nature 467:1061–1073Google Scholar
  2. Asher L, Diesel G, Summers JF, McGreevy PD, Collins LM (2009) Inherited defects in pedigree dogs. Part 1: disorders related to breed standards. Vet J 182:402–411PubMedCrossRefGoogle Scholar
  3. Casal ML, Munuve RM, Janis MA, Werner P, Henthorn PS (2006) Epilepsy in Irish wolfhounds. J Vet Intern Med 20:131–135PubMedCrossRefGoogle Scholar
  4. Chase K, Sargan D, Miller K, Ostrander EA, Lark KG (2006) Understanding the genetics of autoimmune disease: two loci that regulate late onset addison’s disease in Portuguese water dogs. Int J Immunogenet 33:179–184PubMedCrossRefGoogle Scholar
  5. Collins LM, Asher L, Diesel G, Summers JF, McGreevy P (2010) Welfare epidemiology as a tool to assessing the impact of inherited defects in pedigree dogs. Anim Welf 19:67–75Google Scholar
  6. Collins LM, Asher L, Summers J, McGreevy P (2011) Getting priorities straight: risk assessment and decision-making in the improvement of inherited disorders in pedigree dogs. Vet J 189:147–154PubMedCrossRefGoogle Scholar
  7. Ekenstedt KJ, Patterson EE, Minor KM, Mickelson JR (2011) Candidate genes for idiopathic epilepsy in four dog breeds. BMC Genet 12:38PubMedCrossRefGoogle Scholar
  8. Federation Cynologique Internationale (2011) FCI International Breeding Strategies. Available at http://www.fci.be/uploaded_files/29-2010-annex-en.pdf. Accessed 2011
  9. Gough A, Thomas A (2010) Breed predispositions to disease in dogs and cats, 2nd edn. Wiley-Blackwell, OxfordGoogle Scholar
  10. Guo G, Zhou Z, Wang Y, Zhao K, Zhu L, Lust G, Hunter L, Friedenberg S, Li J, Zhang Y, Harris S, Jones P, Sandler J, Krotscheck U, Todhunter R, Zhang Z (2011) Canine hip dysplasia is predictable by genotyping. Osteoarthr Cartil 19:420–429PubMedCrossRefGoogle Scholar
  11. Hayes B, Goddard M (2010) Genome-wide association and genomic selection in animal breeding. Genome 53:876–883PubMedCrossRefGoogle Scholar
  12. Hayes BJ, Bowman PJ, Chamberlain AJ, Goddard ME (2009) Invited review: genomic selection in dairy cattle: progress and challenges. J Dairy Sci 92:433–443PubMedCrossRefGoogle Scholar
  13. Hedhammar ÅA, Malm S, Bonnett B (2011) International and collaborative strategies to enhance genetic health in purebred dogs. Vet J 189:189–196PubMedCrossRefGoogle Scholar
  14. Karlsson EK, Baranowska I, Wade CM, Salmon Hillbertz NHC, Zody MC, Anderson N, Biagi TM, Patterson N, Pielberg GR, Kulbokas EJ, Comstock KE, Keller ET, Mesirov JP, von Euler H, Kampe O, Hedhammar A, Lander ES, Andersson R, Andersson L, Lindblad-Toh K (2007) Efficient mapping of Mendelian traits in dogs through genome-wide association. Nat Genet 39:1321–1328PubMedCrossRefGoogle Scholar
  15. Keller GG, Dziuk E, Bell JS (2011) How the orthopedic foundation for animals (OFA) is tackling inherited disorders in the USA: using hip and elbow dysplasia as examples. Vet J 189:197–202PubMedCrossRefGoogle Scholar
  16. Kinghorn BP (2011) An algorithm for efficient constrained mate selection. Genet Sel Evol 43:4PubMedCrossRefGoogle Scholar
  17. Kinghorn BP, Meszaros SA, Vagg RD (2002) Dynamic tactical decision systems for animal breeding. Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, Montpellier33:179–186.Google Scholar
  18. Lewis TW, Woolliams JA, Blott SC (2010) Optimisation of breeding strategies to reduce the prevalence of inherited disease in pedigree dogs. Anim Welf 19:93–98Google Scholar
  19. Nicholas FW, Crook A, Sargan DR (2011) Internet resources cataloguing inherited disorders in dogs. Vet J 189:132–135PubMedCrossRefGoogle Scholar
  20. O’Neill D, Summers J, Middleton S, Church D, Brodbelt D, McGreevy P, Thomson P (2011) Disease surveillance project in pedigree dogs and cats. Vet Rec 168:414PubMedCrossRefGoogle Scholar
  21. Paster ER, LaFond E, Biery DN, Iriye A, Gregor TP, Shofer FS, Smith GK (2005) Estimates of prevalence of hip dysplasia in golden retrievers and rottweilers and the influence of bias on published prevalence figures. J Am Vet Med Assoc 226:387–392PubMedCrossRefGoogle Scholar
  22. Powers MY, Karbe GT, Gregor TP, McKelvie P, Culp WTN, Fordyce HH, Smith GK (2010) Evaluation of the relationship between orthopedic foundation for animals’ hip joint scores and PennHIP distraction index values in dogs. J Am Vet Med Assoc 237:532–541PubMedCrossRefGoogle Scholar
  23. Shariflou MR, James JW, Nicholas FW, Wade CM (2011) A genealogical survey of Australian registered dog breeds. Vet J 189:203–210PubMedCrossRefGoogle Scholar
  24. Short AD, Catchpole B, Kennedy LJ, Barnes A, Fretwell N, Jones C, Thomson W, Ollier WER (2007) Analysis of candidate susceptibility genes in canine diabetes. J Hered 98:518–525PubMedCrossRefGoogle Scholar
  25. Sorensen MK, Norberg E, Pedersen J, Christensen LG (2008) Invited review: crossbreeding in dairy cattle: a Danish perspective. J Dairy Sci 91:4116–4128PubMedCrossRefGoogle Scholar
  26. Summers JF, Diesel G, Asher L, McGreevy PD, Collins LM (2010) Inherited defects in pedigree dogs. Part 2: disorders that are not related to breed standards. Vet J 183:39–45PubMedCrossRefGoogle Scholar
  27. Thomson PC, Wilson BJ, Wade CM, Shariflou MR, James JW, Tammen I, Raadsma HW, Nicholas FW (2010) The utility of estimated breeding values for inherited disorders of dogs. Vet J 183:243–244PubMedCrossRefGoogle Scholar
  28. Wilbe M, Jokinen P, Truve K, Seppala EH, Karlsson EK, Biagi T, Hughes A, Bannasch D, Andersson G, Hansson-Hamlin H, Lohi H, Lindblad-Toh K (2010) Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. Nat Genet 42:250–254PubMedCrossRefGoogle Scholar
  29. Wilson B, Nicholas FW, Thomson PC (2011) Selection against canine hip dysplasia: success or failure? Vet J 189:160–168PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Faculty of Veterinary ScienceUniversity of SydneySydneyAustralia

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