How host defense is encoded in the mammalian genome
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This issue of Mammalian Genome explores the genetic approach to infectious disease susceptibility as it has been applied in mammals. Although no single issue of any journal could give comprehensive treatment to a field so extensive and rapidly growing as this one, these texts describe key discoveries that provided new understanding of immune responses. Classical genetic studies opened and continue to pave the way to deep understanding of many issues in immunology.
KeywordsNatural Killer Cell Innate Immune System Host Resistance Selective Sweep Autoinflammatory Disease
- Hunn JP, Feng CG, Sher A, Howard JC (this issue) The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens. Mamm Genome 22: doi: 10.1007/s00335-010-9293-3
- Longley R, Smith C, Fortan A, Berghout J, McMorran B, Burgio G, Foote S, Gros P (this issue) Host resistance to malaria: using mouse models to explore the host response. Mamm Genome 22. doi: 10.1007/s00335-010-9302-6
- Marakalala MJ, Kerrigan AM, Brown GD (2011) Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans. Mamm Genome 22. doi: 10.1007/s00335-010-9277-3
- Pyzik M, Gendron-Pontbriand EM, Fodil-Cornu N, Vidal SM (2011) Self or nonself? That is the question: sensing of cytomegalovirus infection by innate immune receptors. Mamm Genome 22. doi: 10.1007/s00335-010-9286-2