Mammalian Genome

, Volume 18, Issue 3, pp 157–163 | Cite as

Integration of mouse phenome data resources

  • The Mouse Phenotype Database Integration Consortium
Informatics

Abstract

Understanding the functions encoded in the mouse genome will be central to an understanding of the genetic basis of human disease. To achieve this it will be essential to be able to characterize the phenotypic consequences of variation and alterations in individual genes. Data on the phenotypes of mouse strains are currently held in a number of different forms (detailed descriptions of mouse lines, first-line phenotyping data on novel mutations, data on the normal features of inbred lines) at many sites worldwide. For the most efficient use of these data sets, we have initiated a process to develop standards for the description of phenotypes (using ontologies) and file formats for the description of phenotyping protocols and phenotype data sets. This process is ongoing and needs to be supported by the wider mouse genetics and phenotyping communities to succeed. We invite interested parties to contact us as we develop this process further.

Notes

Acknowledgments

The authors thank EUMORPHIA (funded by the European Commission under contract number QLG2-CT-2002-00930) and PRIME (funded by the European Commission under contract number LSHG-CT-2005-005283) for supporting their initial meetings.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • The Mouse Phenotype Database Integration Consortium
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 9
    • 10
    • 11
    • 12
    • 13
    • 14
    • 15
    • 16
    • 17
  1. 1.MRC Mammalian Genetics UnitHarwellUK
  2. 2.Wellcome Trust Sanger InstituteHinxtonUK
  3. 3.BSRC FlemingAthensGreece
  4. 4.The Jackson LaboratoryBar HarborUSA
  5. 5.Mammalian Genetics & Genomics Group, Biosciences DivisionOak Ridge National LaboratoryOak RidgeUSA
  6. 6.MRC Human Genetics UnitEdinburghUK
  7. 7.Institute of Experimental GeneticsGSF – National Research Center for Environment and HealthNeuherbergGermany
  8. 8.Department of GeneticsUniversity of CambridgeCambridgeUK
  9. 9.Institut Clinique de la SourisIllkirchFrance
  10. 10.RIKEN Genomic Sciences CenterTsukubaJapan
  11. 11.Helmholtz-Zentrum für Infektionsforschung GmbHBraunschweigGermany
  12. 12.Faculty of Life SciencesUniversity of ManchesterManchesterUK
  13. 13.European Bioinformatics InstituteHinxtonUK
  14. 14.Mouse Biology UnitRomeItaly
  15. 15.Department of Physiology, Development and NeuroscienceUniversity of CambridgeCambridgeUK
  16. 16.Computing LaboratoryOxford UniversityOxfordUK
  17. 17.MRC Mary Lyon CentreHarwellUK

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