A review of statistical methods for expression quantitative trait loci mapping
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With high-throughput technologies now widely available, investigators can easily measure thousands of phenotypes for quantitative trait loci (QTL) mapping. Microarray measurements are particularly amenable to QTL mapping, as evidenced by a number of recent studies demonstrating utility across a broad range of biological endeavors. The early success stories have impelled a rapid increase in both the number and complexity of expression QTL (eQTL) experiments. Consequently, there is a need to consider the statistical principles involved in the design and analysis of these experiments and the methods currently being used. In this article we review these principles and methods and discuss the open questions most likely to yield significant progress toward increasing the amount of meaningful information obtained from eQTL mapping experiments.
KeywordsQuantitative Trait Locus False Discovery Rate Quantitative Trait Locus Mapping Scale Free Network Recombinant Inbred
The authors thank Alan Attie, Meng Chen, Michael Newton, and Brian Yandell for useful discussions and two anonymous reviewers for comments that improved the manuscript. They also thank Stephanie Ciatti for extra help at home.
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