Mammalian Genome

, Volume 17, Issue 4, pp 322–331 | Cite as

The human FK506-binding proteins: characterization of human FKBP19

  • Stuart L. RultenEmail author
  • Ross A. Kinloch
  • Hilda Tateossian
  • Colin Robinson
  • Lucy Gettins
  • John E. Kay


Analysis of the human repertoire of the FK506-binding protein (FKBP) family of peptidyl-prolyl cis/trans isomerases has identified an expansion of genes that code for human FKBPs in the secretory pathway. There are distinct differences in tissue distribution and expression levels of each variant. In this article we describe the characterization of human FKBP19 (Entrez Gene ID: FKBP11), an FK506-binding protein predominantly expressed in vertebrate secretory tissues. The FKBP19 sequence comprises a cleavable N-terminal signal sequence followed by a putative peptidyl-prolyl cis/trans isomerase domain with homology to FKBP12. This domain binds FK506 weakly in vitro. FKBP19 mRNA is abundant in human pancreas and other secretory tissues and high levels of FKBP19 protein are detected in the acinar cells of mouse pancreas.


FK506 Image Clone Secretory Tissue PPIase Domain FKBP Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This project was funded by a BBSRC CASE award sponsored by Pfizer Global Research and Development, Sandwich, UK. The authors thank Dr. Valerie Lucas and Richard Bazin at Pfizer UK for their assistance.


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Stuart L. Rulten
    • 1
    Email author
  • Ross A. Kinloch
    • 2
  • Hilda Tateossian
    • 3
  • Colin Robinson
    • 2
  • Lucy Gettins
    • 2
  • John E. Kay
    • 4
  1. 1.Trafford Centre for Graduate Medical Education and ResearchUniversity of SussexFalmerUK
  2. 2.Discovery Biology DepartmentPfizer Global Research and DevelopmentSandwichUK
  3. 3.MRC Mammalian Genetics UnitHarwellUK
  4. 4.Brighton and Sussex Medical SchoolFalmerUK

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