Mammalian Genome

, Volume 16, Issue 4, pp 273–280 | Cite as

Y chromosome haplotype analysis in purebred dogs

  • Danika L. Bannasch
  • Michael J. Bannasch
  • Jeanne R. Ryun
  • Thomas R. Famula
  • Niels C. Pedersen
Article

Abstract

In order to evaluate the genetic structure of purebred dogs, six Y chromosome microsatellite markers were used to analyze DNA samples from 824 unrelated dogs from 50 recognized breeds. A relatively small number of haplotypes (67) were identified in this large sample set due to extensive sharing of haplotypes between breeds and low haplotype diversity within breeds. Fifteen breeds were characterized by a single Y chromosome haplotype. Breed-specific haplotypes were identified for 26 of the 50 breeds, and haplotype sharing between some breeds indicated a common history. A molecular variance analysis (AMOVA) demonstrated significant genetic variation across breeds (63.7%) and with geographic origin of the breeds (11.5%). A network analysis of the haplotypes revealed further relationships between the breeds as well as deep rooting of many of the breed-specific haplotypes, particularly among breeds of African origin.

References

  1. Bandelt, HJ, Forster, P, Rohl, A 1999Median-joining networks for inferring intraspecific phylogeniesMol Biol Evol163748PubMedGoogle Scholar
  2. Brewer, D, Clark, T, Phillips, A 2001Dogs in Antiquity Anubis to Cerberus The Origins of the Domestic DogAris and PhillipsWarminsterGoogle Scholar
  3. Cavalli–Sforza, LL, Feldman, MW 2003The application of molecular genetic approaches to the study of human evolutionNat Genet33266275CrossRefPubMedGoogle Scholar
  4. Davis, SJM, Valla, FR 1978Evidence for domestication of the dog 12,000 years ago in the natufian of IsraelNature276608610Google Scholar
  5. Forster, P, Rohl, A, Lunnemann, P, Brinkmann, C, Zerjal, T,  et al. 2000short tandem repeat-based phylogeny for the human Y chromosomeAm J Hum Genet67182196PubMedGoogle Scholar
  6. Kayser, M, Krawczak, M, Excoffier, L, Dieltjes, P, Corach, D,  et al. 2001An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populationsAm J Hum Genet689901018PubMedGoogle Scholar
  7. Morris, D 2001DogsTrafalgar SquareNorth PomfretGoogle Scholar
  8. Nobis, G 1979Der alteste haushand lebte vor 14.000 jahrenUmschau79610Google Scholar
  9. Oberbauer, AM, Grossman, DI, Eggleston, ML, Irion, DN, Schaffer, AL,  et al. 2003Alternatives to blood as a source of DNA for large-scale scanning studies of canine genome linkagesVet Res Commun272738PubMedGoogle Scholar
  10. Oliver, M, Lust, G 1998Two DNA sequence specific for the canine Y chromosomeAnim Genet29146149PubMedGoogle Scholar
  11. Olivier, M, Breen, M, Binns, MM, Lust, G 1999Localization and characterization of nucleotide sequences from the canine Y chromosomeChromosome Res7223233PubMedGoogle Scholar
  12. Parker, HG, Kim, LV, Sutter, NB, Carlson, S, Lorentzen, TD,  et al. 2004Genetic structure of the purebred domestic dogScience30411601164CrossRefPubMedGoogle Scholar
  13. Savolainen, P, Zhang, YP, Luo, J, Lundeberg, J, Leitner, T 2002Genetic evidence for an East Asian origin of domestic dogsScience29816101613PubMedGoogle Scholar
  14. Schneider S, Roessli, D, Excoffier L (2000) Arlequin: A software for population genetics data analysis, Ver 2.000. Genetics and Biometry Lab, Department of Anthropology, University of Geneva, Geneva, SwitzerlandGoogle Scholar
  15. Sundqvist, AK, Ellegren, H, Olivier, M, Vila, C 2001Y chromosome haplotyping in Scandinavian wolves (Canis lupus) based on microsatellite markersMol Ecol1019591966PubMedGoogle Scholar
  16. Tchernov, E, Valla, FR 1997Two new dogs and other Natufian dogs form the southern levantJ Archeol Sci246595Google Scholar
  17. Toonen, RJ, Hughes, S 2001Increased throughput for fragment analysis on ABI PRISM 377 automated sequencer using a membrane comb and STR and softwareBiotechniques3113201324PubMedGoogle Scholar
  18. Underhill, PA, Shen, P, Lin, AA, Jin, L, Passarino, G,  et al. 2000Y chromosome sequence variation and the history of human populationsNat Genet26358361CrossRefPubMedGoogle Scholar
  19. Valla, FR 1990Le Natufien: une autre facon de comprendre le mondeJ Israel Prehistoric Soc23171175Google Scholar
  20. Vila, C, Savolainen, P, Maldonado, JE, Amorim, JE, Rice, IR,  et al. 1997Multiple and ancient origins of the domestic dogScience27616871689CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Inc. 2005

Authors and Affiliations

  • Danika L. Bannasch
    • 1
  • Michael J. Bannasch
    • 2
  • Jeanne R. Ryun
    • 1
  • Thomas R. Famula
    • 3
  • Niels C. Pedersen
    • 4
  1. 1.Department of Population Health and Reproduction, School of Veterinary MedicineUniversity of CaliforniaDavisUSA
  2. 2.Center for Companion Animal Health, School of Veterinary MedicineUniversity of CaliforniaDavisUSA
  3. 3.Department of Animal ScienceUniversity of CaliforniaDavisUSA
  4. 4.Department of Medicine and Epidemiology, School of Veterinary MedicineUniversity of CaliforniaDavisUSA

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