Mammalian Genome

, Volume 14, Issue 7, pp 448–453 | Cite as

A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice

  • Paul Denny
  • Elaine Hopes
  • Neill Gingles
  • Karl W. Broman
  • William McPheat
  • John Morten
  • Janet Alexander
  • Peter W. Andrew
  • Steve D. M. Brown


We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F2 generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.


Quantitative Trait Locus Pneumococcal Disease Pneumococcal Infection Fluothane Putative Quantitative Trait Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Martin Farrall and Jonathan Flint for discussions about linkage analysis, and Jackie King for technical support. This work was supported by the Medical Research Council and AstraZeneca UK Limited.


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Copyright information

© Springer-Verlag New York Inc. 2003

Authors and Affiliations

  • Paul Denny
    • 1
  • Elaine Hopes
    • 1
  • Neill Gingles
    • 2
  • Karl W. Broman
    • 3
  • William McPheat
    • 5
  • John Morten
    • 4
  • Janet Alexander
    • 2
  • Peter W. Andrew
    • 2
  • Steve D. M. Brown
    • 1
  1. 1.MRC UK Mouse Genome Centre & Mammalian Genetics Unit, Harwell, Oxon, OX11 0RDUK
  2. 2.Department of Microbiology and ImmunologyUniversity of Leicester, LeicesterUK
  3. 3.Department of BiostatisticsJohns Hopkins University, Baltimore, MarylandUSA
  4. 4.Research and Development GeneticsAstraZeneca, Alderley Park, Macclesfield, CheshireUK
  5. 5.Cell Biology and BiochemistryAstraZeneca R&D Mölndal, Pepparedsleden 1, 431 83 MölndalSweden

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