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Mammalian Genome

, Volume 12, Issue 11, pp 862–866 | Cite as

Cerd4, third member of the d4 gene family: expression and organization of genomic locus

  • Natalia N.  Ninkina
  • Ilja B.  Mertsalov
  • Dina A.  Kulikova
  • Maria V.  Alimova-Kost
  • Olga B.  Simonova
  • Leonid I.  Korochkin
  • Sergey L.  Kiselev
  • Vladimir L.  Buchman
Article

Abstract.

Two members of the d4 family of presumptive transcription modulators, neuro-d4 (Neud4) and ubi-d4/Requiem (Req), have been characterized previously. We cloned and characterized the third member of this gene family, cer-d4 (Cerd4), from chicken and mouse cDNA libraries. The expression patterns of Cerd4 gene in both species are similar and more restricted than expression patterns of other two d4 genes. The main sites of Cerd4 expression are retina and cerebellum, where multiple transcripts could be detected. Two major types of Cerd4 proteins are a full-length isoform possessing all domains characteristic to the d4 family and truncated XZ isoform without C-terminal tandem of PHD fingers. The developmental kinetics of expression of these isoforms is different. The intron/exon structure of human Cerd4 gene is similar to that of neuro-d4 and ubi-d4/Requiem genes, but most introns of Cerd4 gene are much larger than the corresponding introns of the other two genes.

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Copyright information

© Springer-Verlag New York Inc. 2001

Authors and Affiliations

  • Natalia N.  Ninkina
    • 1
  • Ilja B.  Mertsalov
    • 2
  • Dina A.  Kulikova
    • 2
  • Maria V.  Alimova-Kost
    • 2
  • Olga B.  Simonova
    • 2
  • Leonid I.  Korochkin
    • 2
  • Sergey L.  Kiselev
    • 2
  • Vladimir L.  Buchman
    • 1
  1. 1.Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh, EH9 1QH, Scotland, UKGB
  2. 2.Institute of Gene Biology, Russian Academy of Sciences, 34/6, Vavilov Street, Moscow B-334, RussiaRU

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