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Mammalian Genome

, Volume 12, Issue 9, pp 687–694 | Cite as

Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse

  • Ruth M.  Arkell
  • Matthew  Cadman
  • Tracy  Marsland
  • Anne  Southwell
  • Caroline  Thaung
  • Jennifer R.  Davies
  • Toni  Clay
  • Colin V.  Beechey
  • Edward P.  Evans
  • Mark A.  Strivens
  • Steve D.M.  Brown
  • Paul  Denny
Article

Abstract.

The Del(13)Svea36H deletion was recovered from a radiation mutagenesis experiment and represents a valuable resource for investigating gene content and function at this region of mouse Chromosome (Chr) 13 and human Chr 6p21.3-23 and 6p25. In this paper we examine the physical extent of chromosome loss and construct an integrated genetic and radiation hybrid map of the deleted segment. We show that embryos which are homozygous for the deletion die at or before implantation and that heterozygotes are subviable, with a substantial proportion of carriers dying after mid-gestation but before weaning. The majority of viable carriers exhibit a variety of phenotypes including decreased size, eyes open at birth, corneal opacity, tail kinks, and craniofacial abnormalities. Both the heterozygous viability and the penetrance of the visible phenotypes vary with genetic background.

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Copyright information

© Springer-Verlag New York Inc. 2001

Authors and Affiliations

  • Ruth M.  Arkell
    • 1
  • Matthew  Cadman
    • 1
  • Tracy  Marsland
    • 1
  • Anne  Southwell
    • 1
  • Caroline  Thaung
    • 1
  • Jennifer R.  Davies
    • 1
  • Toni  Clay
    • 1
  • Colin V.  Beechey
    • 1
  • Edward P.  Evans
    • 1
  • Mark A.  Strivens
    • 1
  • Steve D.M.  Brown
    • 1
  • Paul  Denny
    • 1
  1. 1.MRC UK Mouse Genome Centre & Mammalian Genetics Unit Harwell, Oxon, OX11 0RD, UKGB

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