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European Radiology

, Volume 29, Issue 12, pp 6443–6446 | Cite as

MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy

  • Tina Pulickal
  • Johannes BoosEmail author
  • Markus Konieczny
  • Lino Morris Sawicki
  • Anja Müller-Lutz
  • Bernd Bittersohl
  • Joachim Gerß
  • Markus Eichner
  • Hans-Jörg Wittsack
  • Gerald Antoch
  • Christoph Schleich
Letter to the Editor

Key Points

Molecular intervertebral disc damage was associated with LBP and radiculopathy.

Patients with radiculopathy and LBP demonstrated a depletion of gagCEST values compared with healthy controls.

GagCEST imaging may be a non-invasive tool for investigation of degeneration processes of lumbar intervertebral discs (IVDs). GagCEST imaging may be an imaging biomarker for biochemical IVD alterations.

Abbreviations

AP

Annulus fibrosus

BMI

Body mass index

CEST

Chemical exchange saturation transfer

GAG

Glycosaminoglycan

GagCEST

Glycosaminoglycan chemical exchange saturation transfer

IVD

Intervertebral disc

LBP

Lower back pain

MRI

Magnetic resonance imaging

NP

Nucleus pulposus

RF

Radiofrequency

ROI

Region of interest

SLRasym

Asymmetric spin-lock ratio

VAS

Visual analogue scale

WASABI

Water Saturation and B1

WHO

World Health Organization

Notes

Acknowledgments

We would like to thank Erika Rädisch for the assistance in receiving the MRI scans.

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is C. Schleich.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

Joachim Gerß (Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany) kindly provided statistical advice for this manuscript.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• prospective

• diagnostic or prognostic study

• performed at one institution

Supplementary material

330_2019_6305_MOESM1_ESM.docx (6.7 mb)
ESM 1 (DOCX 6862 kb)

References

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Copyright information

© European Society of Radiology 2019

Authors and Affiliations

  • Tina Pulickal
    • 1
  • Johannes Boos
    • 1
    Email author
  • Markus Konieczny
    • 2
  • Lino Morris Sawicki
    • 1
  • Anja Müller-Lutz
    • 1
  • Bernd Bittersohl
    • 2
  • Joachim Gerß
    • 3
  • Markus Eichner
    • 1
  • Hans-Jörg Wittsack
    • 1
  • Gerald Antoch
    • 1
  • Christoph Schleich
    • 1
  1. 1.Medical Faculty, Department of Diagnostic and Interventional RadiologyUniversity DusseldorfDusseldorfGermany
  2. 2.Medical Faculty, Department of OrthopedicsUniversity DusseldorfDusseldorfGermany
  3. 3.Institute of Biostatistics and Clinical ResearchUniversity of MuensterMuensterGermany

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