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European Radiology

, Volume 30, Issue 1, pp 301–307 | Cite as

Wall enhancement of intracranial saccular and fusiform aneurysms may differ in intensity and extension: a pilot study using 7-T high-resolution black-blood MRI

  • Xinke Liu
  • Zihao Zhang
  • Chengcheng Zhu
  • Junqiang Feng
  • Peng Liu
  • Qingle Kong
  • Xianchang Zhang
  • Qiang Zhang
  • Hengwei Jin
  • Huijian Ge
  • Yuhua JiangEmail author
  • David Saloner
  • Youxiang LiEmail author
Magnetic Resonance
  • 102 Downloads

Abstract

Purpose

To evaluate and compare wall enhancement patterns in saccular and fusiform intracranial aneurysms using high-resolution black-blood MRI at 7 T.

Methods

Thirty-one patients with 32 unruptured intracranial aneurysms (21 saccular and 11 fusiform) underwent 7-T black-blood MRI. Aneurysm wall enhancement (AWE) was categorized as follows: no wall enhancement (NWE), focal wall enhancement (FWE), and uniform wall enhancement (UWE). The degree of enhancement was scored as follows: 0 (no enhancement), 1 (signal intensity (SI) of the aneurysm wall less than that of the pituitary infundibulum), and 2 (equal to that of the pituitary infundibulum). The chi-squared test was used to compare the AWE pattern and degree between saccular and fusiform aneurysms.

Results

In saccular aneurysms, 12/21 (57%) enhanced. Of these, 9 showed FWE (5 grade 1 and 4 grade 2), and 3 showed UWE (2 grade 1 and 1 grade 2). In fusiform aneurysms, 11/11 (100%) enhanced. Of these, 1 showed FWE and 10 showed UWE. All fusiform aneurysms had grade-2 enhancement. Fusiform aneurysms had more extensive and higher SI AWE than saccular aneurysms (p < 0.01) despite having a similar size (6.9 ± 3.0 mm vs. 8.0 ± 2.9, p = 0.23). For saccular aneurysm, larger aneurysm size was correlated with higher degree of enhancement with Pearson’s r = 0.64 (p = 0.002).

Conclusion

Intracranial fusiform aneurysms had enhancement of higher SI and that covered a more extensive area than saccular aneurysms, which might indicate differences in vessel wall pathology.

Key Points

• Intracranial aneurysm wall enhancement can be reliably characterized by 7-T black-blood MRI.

• AWE in intracranial fusiform aneurysms presents over a larger surface area and with greater signal intensity as compared with that in saccular aneurysms, which might indicate differences in pathology.

• Stronger signal intensity of AWE correlates with the aneurysm size in saccular aneurysms.

Keywords

Magnetic resonance imaging Gadolinium Saccular aneurysm Fusiform aneurysm Pathology 

Abbreviations

AWE

Aneurysm wall enhancement

DANTE

Delay alternating with nutation for tailored excitation

ER

Enhancement ratio

FEW

Focal wall enhancement

iMSDE

Improved motion-sensitized driven-equilibrium

MPR

Multiplanar reconstruction

NEW

No wall enhancement

SI

Signal intensity

SPACE

Fast spin echo with variable flip angle trains

UWE

Uniform wall enhancement

Notes

Acknowledgments

We sincerely thank all the patients and health care workers who participated in this study.

Funding

The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: “National Key R&D Program of China,” grant no. Z161100002616002; “Scientific and Technological Projects of Science and Technology Commission of Beijing,” grant no. 2017YFB1304400.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Youxiang Li.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• Prospective

• Observational

• Performed at one institution

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Copyright information

© European Society of Radiology 2019

Authors and Affiliations

  • Xinke Liu
    • 1
  • Zihao Zhang
    • 2
    • 3
  • Chengcheng Zhu
    • 4
  • Junqiang Feng
    • 1
  • Peng Liu
    • 1
  • Qingle Kong
    • 2
    • 5
  • Xianchang Zhang
    • 2
    • 5
  • Qiang Zhang
    • 6
  • Hengwei Jin
    • 1
  • Huijian Ge
    • 1
  • Yuhua Jiang
    • 1
    Email author
  • David Saloner
    • 4
  • Youxiang Li
    • 1
    Email author
  1. 1.Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina
  2. 2.State Key Laboratory of Brain and Cognitive Science, Institute of BiophysicsChinese Academy of SciencesBeijingChina
  3. 3.The Innovation Center of Excellence on Brain ScienceChinese Academy of SciencesBeijingChina
  4. 4.Department of Radiology and Biomedical ImagingUniversity of California San FranciscoSan FranciscoUSA
  5. 5.University of Chinese Academy of SciencesBeijingChina
  6. 6.Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of MedicineTsinghua UniversityBeijingChina

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