Prognostic value of ADC quantification for clinical outcome in uterine cervical cancer treated with concurrent chemoradiotherapy
To investigate the prognostic value of diffusion-weighted imaging (DWI) in predicting clinical outcome in patients with cervical cancer after concurrent chemoradiotherapy (CCRT).
We enrolled 124 cervical cancer patients who received definitive CCRT and underwent 3 T-MRI before and 1 month after initiating treatment. The mean apparent diffusion coefficient (ADC) value was measured on the tumor and the changes in ADC percentage (ΔADCmean) between the two time points were calculated. The Cox proportion hazard model was used to evaluate the associations between imaging or clinical variables and progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS).
In multivariate analysis, ΔADCmean was the only independent predictor of PFS (hazard ratio [HR] = 0.2379, p = 0.005), CSS (HR = 0.310, p = 0.024), and OS (HR = 0.217, p = 0.002). Squamous cell carcinoma antigen, histology, and pretreatment tumor size were significantly independent predictors of PFS. Tumor size response was significantly independent predictor of CSS and OS. Using the cutoff values of ΔADCmean, the PFS was significantly lower for ΔADCmean < 27.8% (p = 0.001). The CSS and OS were significantly lower for ΔADCmean < 16.1% (p = 0.002 and p < 0.001, respectively).
The percentage change in tumor ADC may be a useful predictor of disease progression and survival in patients with cervical cancer treated with CCRT.
• DWI is widely used as a potential marker of tumor viability.
• Percentage change in tumor ADC (ΔADC mean ) was an independent marker of PFS, CSS, and OS.
• Survival was better in patients with ≥ ΔADC mean cutoff value than with < the cutoff value.
KeywordsDiffusion-weighted imaging Cervical cancer Concurrent chemoradiotherapy Treatment outcome Magnetic resonance imaging
Apparent diffusion coefficient
International Federation of Gynecology and Obstetrics
Intraclass correlation coefficient
Magnetic resonance imaging
Region of interest
Squamous cell carcinoma
T1-weighted high-resolution isotropic volume examination
Percentage change of mean ADC between two time points
We thank Hye Seung Kim, MS, and Insuk Sohn, PhD, of the Statistics and Data Center, Samsung Medical Center, for statistical assistance.
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1A2B4006020).
Compliance with ethical standards
The scientific guarantor of this publication is Chan Kyo Kim.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
Hye Seung Kim, MD and Insuk Sohn, PhD kindly provided statistical advice for this manuscript.
Written informed consent was waived by the Institutional Review Board.
Institutional Review Board approval was obtained.
• diagnostic or prognostic study
• performed at one institution
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