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Pancreas shrinkage following recurrent acute pancreatitis: an MRI study

  • Steve V. DeSouza
  • Sunitha Priya
  • Jaelim Cho
  • Ruma G. Singh
  • Maxim S. PetrovEmail author
Hepatobiliary-Pancreas
  • 31 Downloads

Abstract

Objective

Transition from the first attack of acute pancreatitis (AP) to chronic pancreatitis (CP) via recurrent AP is common. Total pancreas volume (TPV) and pancreas diameters are often reduced in advanced CP but have never been studied after AP. The objective of this study was to investigate pancreas size after clinical resolution of AP and its association with the number of AP attacks.

Methods

Individuals with a history of AP were grouped based on the number of attacks (1, 2, ≥ 3 attacks). Healthy individuals were also recruited. All participants underwent magnetic resonance imaging, from which TPV and pancreas diameters (across the head, body, and tail) were measured independently by two raters in a blinded fashion. Generalised additive models (including age, sex, body mass index, and glycated haemoglobin levels) were used.

Results

A total of 123 participants were studied. Total pancreas volume and tail diameter were significantly reduced in both unadjusted (TPV (p = 0.036), tail diameter (p = 0.009)) and adjusted (TPV (p = 0.026), tail diameter (p = 0.034)) models in individuals with ≥ 3 attacks, but not with 1 or 2 attacks, compared with healthy individuals. Head and body diameters did not differ significantly.

Conclusions

Reduced TPV and tail diameter characterise individuals after ≥ 3 attacks of AP and may represent one of the earliest irreversible morphological changes in individuals after AP. A high-risk population for transition to CP might include individuals with at least 3 attacks of AP whereas those with less than 3 attacks might be at a low risk.

Key Points

• A significant reduction in total pancreas volume was demonstrated in individuals after 3 or more attacks of acute pancreatitis (without conventional signs of chronic pancreatitis).

• Pancreas tail diameter, but not head or body diameter, was reduced in individuals after 3 or more attacks of acute pancreatitis (without conventional signs of chronic pancreatitis).

• The above findings were independent of age, sex, body mass index, and glycated haemoglobin levels.

Keywords

Magnetic resonance imaging Pancreas Pancreatitis Recurrence 

Abbreviations

AP

Acute pancreatitis

AUC

Area under the curve

BMI

Body mass index

CI

Confidence interval

CP

Chronic pancreatitis

CRP

C-reactive protein

GAM

Generalised additive model

HbA1c

Glycated haemoglobin

ICC

Intra-class correlation coefficient

IQR

Interquartile range

MR

Magnetic resonance

TPV

Total pancreas volume

Notes

Acknowledgements

This study was part of the Clinical and epidemiOlogical inveStigations in Metabolism, nutritiOn, and pancreatic diseaseS (COSMOS) program.

Funding

COSMOS is supported, in part, by the Royal Society of New Zealand (Rutherford Discovery Fellowship to Associate Professor Max Petrov).

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Associate Professor Max Petrov, MD, MPH, PhD.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

Two of the authors have significant statistical expertise.

Informed consent

Written informed consent was obtained from all participants in this study.

Ethical approval

Health and Disability Ethics Committee approval was obtained.

Methodology

• prospective

• cross-sectional study

• performed at one institution

Supplementary material

330_2019_6126_MOESM1_ESM.docx (16 kb)
ESM 1 (DOCX 16 kb)

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Copyright information

© European Society of Radiology 2019

Authors and Affiliations

  1. 1.School of MedicineUniversity of AucklandAucklandNew Zealand
  2. 2.Auckland City HospitalAucklandNew Zealand

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