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European Radiology

, Volume 29, Issue 11, pp 5861–5872 | Cite as

Predicting liver failure after extended right hepatectomy following right portal vein embolization with gadoxetic acid-enhanced MRI

  • Dorothea TheiligEmail author
  • Ingo Steffen
  • Maciej Malinowski
  • Martin Stockmann
  • Daniel Seehofer
  • Johann Pratschke
  • Bernd Hamm
  • Timm Denecke
  • Dominik Geisel
Magnetic Resonance
  • 142 Downloads

Abstract

Objectives

Predicting post-hepatectomy liver failure (PHLF) after extended right hepatectomy following portal vein embolization (PVE) from serial gadoxetic acid-enhanced magnetic resonance imaging (MRI).

Methods

Thirty-six patients who underwent hepatectomy following PVE were evaluated prospectively with gadoxetic acid-enhanced MRI examinations at predefined intervals during the course of their treatment, i.e., before and 14 days and 28 days after PVE as well as 10 days after hepatectomy. Relative enhancement (RE) and volume of the left and right liver lobes were determined. The study population was divided into two groups with respect to signs of PHLF. Differences between the two groups were assessed using the Mann-Whitney U test, and predictive parameters for group membership were investigated using ROC and logistic regression analysis.

Results

RE of the left lobe prior to PVE versus 14 days after PVE was significantly lower in patients with PHLF than in those without PHLF (Mann-Whitney U test p < 0.001) and proved to be the best predictor of PHLF in ROC analysis with an AUC of 0.854 (p < 0.001) and a cutoff value of − 0.044 with 75.0% sensitivity and 92.6% specificity. Consistent with this result, logistic linear regression analysis adjusted for age identified the same parameter to be a significant predictor of PHLF (p = 0.040).

Conclusions

Gadoxetic acid-enhanced MRI performed as an imaging-based liver function test before and after PVE can help to predict PHLF. The risk of PHLF can be predicted as early as 14 days after PVE.

Key Points

To predict the likelihood of post-hepatectomy liver failure, it is important to estimate not only future liver remnant volume prior to extended liver resection but also future liver remnant function.

Future liver remnant function can be predicted by performing gadoxetic acid-enhanced MRI as an imaging-based liver function test before and after portal vein embolization.

A reduction of relative enhancement of the liver in gadoxetic acid-enhanced MRI after portal vein embolization of 0.044 predicts post-hepatectomy liver failure with 75.0% sensitivity and 92.6% specificity.

Keywords

Liver Hepatectomy Contrast agent Magnetic resonance imaging 

Abbreviations

ALBI

Albumin-bilirubin

FLR-F

Future liver remnant function

FLR-V

Future liver remnant volume

KGR

Kinetic growth rate

LiMAx

13C-Methacetin breath test

LLL

Left liver lobe

PHLF

Post-hepatectomy liver failure

PVE

Portal vein embolization

RE

Relative enhancement

RLL

Right liver lobe

Notes

Acknowledgements

The authors thank Bettina Herwig for language editing.

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Dominik Geisel.

Conflict of interest

Drs Geisel, Hamm, and Denecke have received travel support and honoraria from Bayer AG.

Statistics and biometry

One of the authors has significant statistical expertise.

Informed consent

Written informed consent was obtained from all patients in this study.

Ethical approval

Institutional review board approval was obtained.

Study subjects or cohorts overlap

The 36 patients included in the current study have already been the subject of an earlier report [23]. The prior study investigated the increase in liver volume and the potential of gadoxetic acid-enhanced MRI to predict the volume increase and monitor the functional increase of the future liver remnant after portal vein embolization. With a longer observation period until the point well after extended hemihepatectomy following portal vein embolization and newly available information of the outcome of surgery and clinical status afterwards, the focus of the current study is on clinical outcome and means of predicting this outcome using several functional parameters including gadoxetic acid-enhanced MRI.

Methodology

• prospective study

• diagnostic or prognostic study

• performed at one institution

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Copyright information

© European Society of Radiology 2019

Authors and Affiliations

  1. 1.Department of Diagnostic and Interventional RadiologyCharité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu BerlinBerlinGermany
  2. 2.Division of Oncology and Hematology, Department of PediatricsCharité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu BerlinBerlinGermany
  3. 3.Department of General, Visceral and Transplantation SurgeryCharité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu BerlinBerlinGermany
  4. 4.Department of Visceral, Transplantation, Vascular and Thoracic SurgeryUniversity Hospital of LeipzigLeipzigGermany

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