Modified CAIPIRINHA-VIBE without view-sharing on gadoxetic acid–enhanced multi-arterial phase MR imaging for diagnosing hepatocellular carcinoma: comparison with the CAIPIRINHA-Dixon-TWIST-VIBE

  • Seung Baek Hong
  • Nam Kyung LeeEmail author
  • Suk Kim
  • Hyeong Il Seo
  • Hyun Sung Kim
  • Dong Uk Kim
  • Tae Un Kim
  • Hwa Seong Ryu
Magnetic Resonance



We evaluated the detection rate and degree of motion artifact of the modified CAIPIRINHA-VIBE (mC-VIBE) without view-sharing and compare them with the CAIPIRINHA-Dixon-TWIST-VIBE (CDT-VIBE) with view-sharing on multi-arterial gadoxetic acid–enhanced liver MRI in the assessment of hepatocellular carcinoma (HCC).

Material and methods

We retrospectively identified 114 pathological-proven hepatic tumors in 114 patients with risk of HCC who underwent multi-arterial gadoxetic acid–enhanced MRI between June 2016 and June 2018. All patients underwent triple arterial phase imaging using the mC-VIBE without view-sharing (54 patients; 49 HCCs and 5 non-HCCs) or the CDT-VIBE with view-sharing (60 patients; 55 HCCs and 5 non-HCCs). We compared the detection rate of two sequences for HCC, with reference to LI-RADS.V.2017. We also compared the mean motion scores and proportions of transient severe motion (TSM) in two sequences.


For the examination using the mC-VIBE, the HCC-detection rate was significantly higher, compared with that using CDT-VIBE (93.9% [46/49] vs 80.0% [44/55], respectively; p = 0.047). For the examination with the mC-VIBE, mean motion scores were significantly lower compared with those of CDT-VIBE for all multi-arterial phases (1.21, 1.19, and 1.15 vs. 1.82, 1.85, and 1.84, respectively; p < 0.001 for all three comparisons). The proportion of TSM in the CDT-VIBE was significantly higher than that in the mC-VIBE (15.0% [9/60] vs 0.0% [0/54], respectively; p = 0.003).


In multi-arterial phase gadoxetic acid–enhanced MRI, the mC-VIBE sequence without view-sharing has slightly higher HCC-detection rate and fewer motion artifacts compared with CDT-VIBE with view-sharing.

Key Points

Multi-arterial phase using the mC-VIBE without view-sharing can overcome motion artifacts, resulting in providing optimal arterial phase imaging.

The HCC-detection rate is slightly higher with the mC-VIBE vs. CAIPIRINHA-Dixon-TWIST-VIBE with view-sharing (CDT-VIBE).

View-sharing of CDT-VIBE in the multi-arterial phase is associated with increased frequency of TSM.


Magnetic resonance imaging Hepatocellular carcinoma Gadoxetic acid Detection Artifact 



Arterial phase hyperenhancement


Controlled aliasing in parallel imaging results in higher acceleration factor






Transient severe motion


Time-resolved angiography with interleaved stochastic trajectories


Volumetric interpolated breath-hold examination



The authors state that this work has not received any funding.

Compliance with ethical standards


The scientific guarantor of this publication is Nam Kyung Lee.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Ethical approval

Institutional Review Board approval was obtained.


• retrospective

• diagnostic or prognostic study

• performed at one institution


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Copyright information

© European Society of Radiology 2019

Authors and Affiliations

  1. 1.Department of Radiology, Biomedical Research InstitutePusan National University Hospital, and Pusan National University School of MedicineBusanSouth Korea
  2. 2.Department of Surgery, Biomedical Research InstitutePusan National University Hospital, and Pusan National University School of MedicineBusanSouth Korea
  3. 3.Department of Surgery, Biomedical Research InstitutePusan National University Yangsan Hospital, and Pusan National University School of MedicineBusanSouth Korea
  4. 4.Department of Internal Medicine, Biomedical Research InstitutePusan National University Hospital, and Pusan National University School of MedicineBusanSouth Korea
  5. 5.Department of Radiology, Biomedical Research InstitutePusan National University Yangsan Hospital, and Pusan National University School of MedicineBusanSouth Korea

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